Awadelkareem, Amir Mahgoub; Al-Shammari, Eyad; Elkhalifa, Abd Elmoneim O.; Adnan, Mohd; Siddiqui, Arif Jamal; Snoussi, Mejdi; Khan, Mohammad Idreesh; Azad, Z. R. Azaz Ahmad; Patel, Mitesh; Ashraf, Syed Amir published an article in 2022, the title of the article was Phytochemical and In Silico ADME/Tox Analysis of Eruca sativa Extract with Antioxidant, Antibacterial and Anticancer Potential against Caco-2 and HCT-116 Colorectal Carcinoma Cell Lines.HPLC of Formula: 85-91-6 And the article contains the following content:
Eruca sativa Mill. (E. sativa) leaves recently grabbed the attention of scientific communities around the world due to its potent bioactivity. Therefore, the present study investigates the metabolite profiling of the ethanolic crude extract of E. sativa leaves using high resolution-liquid chromatog.-mass spectrometry (HR-LC/MS), including antibacterial, antioxidant and anticancer potential against human colorectal carcinoma cell lines. In addition, computer-aided anal. was performed for determining the pharmacokinetic properties and toxicity prediction of the identified compounds Our results show that E. sativa contains several bioactive compounds, such as vitamins, fatty acids, alkaloids, flavonoids, terpenoids and phenols. Furthermore, the antibacterial assay of E. sativa extract showed inhibitory effects of the tested pathogenic bacterial strains. Moreover, the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) were found to be IC50 = 66.16 μg/mL and 76.05 μg/mL, resp. E. sativa also showed promising anticancer activity against both the colorectal cancer cells HCT-116 (IC50 = 64.91 μg/mL) and Caco-2 (IC50 = 83.98 μg/mL) in a dose/time dependent manner. The phytoconstituents identified showed promising pharmacokinetics properties, representing a valuable source for drug or nutraceutical development. These investigations will lead to the further exploration as well as development of E. sativa-based nutraceutical products. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).HPLC of Formula: 85-91-6
The Article related to gene expression eruca antioxidant antibacterial anticancer agent colorectal carcinoma, eruca sativa, bioactive compounds, colorectal cancer, erucin, isothiocyanates, jarjeer, nutraceutical, phytochemical analysis and other aspects.HPLC of Formula: 85-91-6
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