Young, Nicholas; Hobbs, Mark; Rahnama, Fahimeh; Shi, Jinyang; Briggs, Simon published the artcile< An observational study of high- and low-abundance anti-retroviral resistance mutations among treatment-naive people living with HIV in New Zealand between 2012 and 2017>, Category: esters-buliding-blocks, the main research area is DRM HIV infection; Australasia; HIV infection; anti-HIV agent; anti-retroviral agent; high-throughput nucleotide sequencing; integrase inhibitor.
HIV resistance genotyping detects drug resistance mutations (DRMs) in ≥20% of circulating virus within an infected individual (high-abundance DRMs). Deep sequencing also detects DRMs in smaller viral subpopulations (low-abundance DRMs), although these are of uncertain importance. In this retrospective anal. of 292 treatment-naive patients, high-abundance DRMs were present in 30/292 (10%) patients, but only one (0.3%) had resistance to first-line anti-retrovirals. Low-abundance DRMs were present in 36/247 (15%) patients, but none who received anti-retrovirals for which these were present had virol. failure. These findings demonstrate that starting first-line therapy in treatment-naive patients need not be delayed while awaiting resistance testing.
Internal Medicine Journal published new progress about Antiviral agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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