Wang, Lei; Ni, Qijian; Bluemel, Marcus; Shu, Tao; Raabe, Gerhard; Enders, Dieter published the artcile< NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides>, Synthetic Route of 112-63-0, the main research area is succinimide preparation enantioselective diastereoselective; ketoamide aldehyde cycloaddition heterocyclic carbene catalyst; N-heterocyclic carbenes; asymmetric synthesis; ketoamides; organocatalysis; succinimides.
The efficient asym. synthesis of highly substituted succinimides (3R/3S,4R) I (R = 2-ClC6H4, 4-H3COC6H4, 3-thienyl, etc.; R1 = CH3, 4-H3CC6H4, 2-furyl; R2 = C6H5, 3-ClC6H4, 4-H3COC6H4, 2-(methoxycarbonyl)-3-thienyl) from α,β-unsaturated aldehydes and α-ketoamides via N-heterocyclic carbene (NHC) catalyzed [3+2] cycloaddition has been developed. The new scalable protocol significantly expands the utility of NHC catalysis for the synthesis of heterocycles II (X = C6H5, 4-H3COC6H4; Y = C6H5, 2-furyl; Z = C6H5, 2-(methoxycarbonyl)-3-thienyl) and provides easy access to assemble a wide range of succinimides I from simple starting materials.
Chemistry – A European Journal published new progress about [3+2] Cycloaddition reaction, stereoselective ((3+2)). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics