Santi, Micol; Ould, Darren M. C.; Wenz, Jan; Soltani, Yashar; Melen, Rebecca L.; Wirth, Thomas published the artcile< Metal-Free Tandem Rearrangement/Lactonization: Access to 3,3-Disubstituted Benzofuran-2-(3H)-ones>, Category: esters-buliding-blocks, the main research area is benzofuranone preparation; diazoester preparation tandem rearrangement lactonization; benzofuranone; boron; diazo compounds; metal-free conditions; rearrangement.
A novel metal-free synthesis of 3,3-disubstituted benzofuran-2-(3H)-ones through reacting α-aryl-α-diazoacetates with triarylboranes is presented. Initially, triarylboranes were successfully investigated in α-arylations of α-diazoacetates, however in the presence of a heteroatom in the ortho position, the boron enolate intermediate undergoes an intramol. rearrangement to form a quaternary center. The intermediate cyclizes to afford valuable 3,3-disubstituted benzofuranones in good yields.
Angewandte Chemie, International Edition published new progress about Arylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics