Kim, Hichul; El-Khoury, Victoria; Schulte, Nadine; Zhan, Tianzuo; Betge, Johannes; Cousin, Loic; Felli, Emanuele; Pessaux, Patrick; Ogier, Arnaud; Opitz, Oliver; Ku, Bosung; Ebert, Matthias P.; Kwon, Yong-Jun published the artcile< Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid>, Product Details of C19H34O2, the main research area is human metastatic lung atypical carcinoid spheroid bevacizumab capecitabine; Personalized functional profiling; antiangiogenic therapy; drug screening; lung carcinoid; neuroendocrine tumors; personalized medicine; pharmacotyping; precision medicine; spheroids.
Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i.e. drug screening, was performed in ex-vivo spheroids obtained from the patient liver metastasis to identify potential therapeutic options. The drug screening results revealed cediranib, an antiangiogenic drug, as a hit drug for this patient, from a library of 66 Food and Drug Administration (FDA)-approved and investigational drugs. Based on the PFP results and the reported evidence of clin. efficacy of bevacizumab and capecitabine combination in gastro-intestinal neuroendocrine tumors, this combination was given to the patient. Four months later, the pleural effusion and pleura carcinosis regressed and the liver metastasis did not progress. The patient experienced 2 years of a stable disease under the PFP-guided personalized treatment.
Cancer Biology & Therapy published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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