Ikura, Masahiro; Nakatani, Shingo; Yamamoto, Shingo; Habashita, Hiromu; Sugiura, Tsuneyuki; Takahashi, Kanji; Ogawa, Koji; Ohno, Hiroyuki; Nakai, Hisao; Toda, Masaaki published the artcile< Discovery of a new chemical lead for a matrix metalloproteinase inhibitor>, COA of Formula: C6H10O5, the main research area is benzoyl aminobutyric hydroxamic acid derivative preparation matrix metalloproteinase inhibitor.
A series of N-benzoyl γ-aminobutyric hydroxamic acids were synthesized and evaluated as matrix metalloproteinase inhibitors. First, the authors focused on chem. modification of the N-benzoyl residue. Introduction of electron-rich para-substituents was effective to increase the inhibitory activity. Especially, some of the analogs with relatively more planar N-acyl residues, such as (I) and (II), demonstrated more potent activity. Second, chem. modification of the γ-aminobutyric hydroxamic acid moiety was carried out to optimize the three-dimensional arrangement of the two pharmacophores (hydroxamic acid and N-acyl residues). Among the tested, the γ-aminobutyric hydroxamic acid moiety was found to be the best spacer for connecting the above-mentioned two pharmacophores. Synthesis and structure-activity relationships are discussed.
Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics