dos Santos Pedroso-Fidelis, Giulia; de Melo, Maria Eduarda; Possato, Jonathann Correa; Fernandes, Bruna Barros; De Pieri, Ellen; Cercena, Rodrigo; Dal-Bo, Alexandre Goncalves; Feuser, Paulo Emilio; Machado-de-Avila, Ricardo Andrez published the artcile< Temozolomide associated to gold nanoparticles promoted a synergic effect and apoptosis when exposed to melanoma cells>, Application In Synthesis of 112-63-0, the main research area is temozolomide gold nanoparticle synergic effect apoptosis melanoma.
Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent studies have shown that gold nanoparticles (GNPs) with their biocompatibility and cytotoxic potential in tumor cells can be combined with chemotherapy leading to an improvement in the existing treatment. Thus, this work aimed to evaluate the cytotoxic effects of TMZ associated with GNPs (T-GNPs) on B16F10 cells. Different GNPs were successfully synthesized, and the results showed that there was an electrostatic interaction between TMZ and GNPs, not changing their physicochem. properties. TMZ associated with GNPs exposed on B16F10 cells presented a cytotoxic effect even more pronounced than free TMZ. In addition, different T-GNPs did not induced cytotoxic effect on non-tumor cells (NIH3T3 and red blood cells). A synergism between TMZ and GNPs was observed, inducing B16F10 cell death by apoptosis.
Journal of Nanoparticle Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
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