De Vrieze, Jana; Van Herck, Simon; Nuhn, Lutz; De Geest, Bruno G. published the artcile< Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent>, Formula: C9H3F5O2, the main research area is pH polymer lipid amphiphile ketal RAFT chain transfer agent; amphiphiles; degradability; ketal; lipid conjugation; reversible addition-fragmentation chain transfer.
Conjugation of small mol. drug to lipid-polymer amphiphiles is a powerful strategy to alter the pharmacokinetic profile of these mols. by promoting binding to albumin or other serum mols. Incorporation of a responsive linker between the lipid anchor and the polymer chain can be of interest to avoid indefinite binding of the conjugates to hydrophobic pockets of serum proteins or phospholipid membranes when reaching a target cell or tissue. Here, the synthesis of pH-sensitive lipid-polymer conjugates by reversible addition-fragmentation chain transfer (RAFT) polymerization using a RAFT chain transfer agent that is equipped with a pH-sensitive ketal bond between a cholesterol moiety and the trithiocarbonate RAFT chain transfer group is reported. It is demonstrated that in native form these conjugates exhibit a high affinity to albumin and cell membranes but loose this ability in response to a mild acidic trigger in aqueous medium.
Macromolecular Rapid Communications published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Formula: C9H3F5O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics