Dai, Wang-Ying; Luo, Zong-Ping published the artcile< Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is intervertebral disk paeoniflorin pyroptosis nucleus pulposus cell.
Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disk in rats. PF improves MRI T2-weighted phase parameters of intervertebral disk degeneration caused by puncture. PF attenuates matrix degradation and lactic acid accumulation during intervertebral disk degeneration caused by puncture. The protein expressions of collagen II, aggrecan, MMP3, and MMP13 in the intervertebral disks of the three groups of rats were detected by immunohistochem. at 2 wk postoperatively. Semi-quant. immunohistochem. anal. of collagen II, aggrecan, MMP3, and MMP13. Lactic acid content in the intervertebral disks of rats from the three exptl. groups of at 2 wk post-surgery as determined by ELISA. In this study, the intracellular calcium level in NPCs was significantly reduced by PF treatment; thus, the attenuation of pyroptosis by PF may be related to its inhibitory effect on intracellular calcium level. Based on this, channels that regulate intracellular calcium concentration in acidic environments may become therapeutic targets. PF reduced the intracellular calcium level, inhibited pyroptosis of NPCs, and delayed IVDD.
Cellular Signalling published new progress about Acid-sensing ion channel ASIC1a Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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