Collett, Christopher J.; Young, Claire M.; Massey, Richard S.; O’Donoghue, AnnMarie C.; Smith, Andrew D. published the artcile< Kinetic and Structure-Activity Studies of the Triazolium Ion- Catalyzed Intramolecular Stetter Reaction>, Reference of 112-63-0, the main research area is ethyl formylphenoxy butenoate heterocyclic carbene Stetter reaction mechanism kinetics.
Mechanistic studies of the triazolium ion-catalyzed intramol. Stetter reaction using initial rates anal. in NEt3/NEt3 · HCl buffered methanol showed the reaction to be first-order in catalyst and zero-order in aldehyde over a broad range of aldehyde concentrations The observed reaction rate is higher for catalysts bearing N-aryl substituents with electron-withdrawing groups. A concurrent, NHC-independent substrate isomerization was also observed and found to demonstrate a first-order dependence on aldehyde concentration The reported data are consistent with deprotonation to form the Breslow intermediate being turnover-limiting in this process.
European Journal of Organic Chemistry published new progress about Cis-trans isomerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
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