Zhao, Xin; Cui, Lijuan; Zhang, Yushan; Guo, Chao; Deng, Lijiao; Wen, Zhitong; Lu, Zhihong; Shi, Xiaoyuan; Xing, Haojie; Liu, Yunfeng; Zhang, Yi published the artcile< Screening for potential therapeutic agents for non-small cell lung cancer by targeting ferroptosis>, COA of Formula: C15H22N2O2, the main research area is NSCLC ferroptosis therapeutic agent screening target.
Ferroptosis is a form of non-apoptotic and iron-dependent cell death originally identified in cancer cells. Recently, emerging evidence showed that ferroptosis-targeting therapy could be a novel promising anti-tumor treatment. However, systematic analyses of ferroptosis-related genes for the prognosis of non-small cell lung cancer (NSCLC) and the development of antitumor drugs exploiting the ferroptosis process remain rare. This study aimed to identify genes related to ferroptosis and NSCLC and to initially screen lead compounds that induce ferroptosis in tumor cells. We downloaded mRNA expression profiles and NSCLC clin. data from The Cancer Genome Atlas database to explore the prognostic role of ferroptosis-related genes. Four prognosis-associated ferroptosis-related genes were screened using univariate Cox regression anal. and the lasso Cox regression anal., which could divide patients with NSCLC into high- and low-risk groups. Then, based on differentially expressed risk- and ferroptosis-related genes, the neg. correlated lead compound flufenamic acid (FFA) was screened through the Connective Map database. This project confirmed that FFA induced ferroptosis in A549 cells and inhibited growth and migration in a dose-dependent manner through CCK-8, scratch, and immunofluorescence assays. In conclusion, targeting ferroptosis might be a therapeutic alternative for NSCLC.
Frontiers in Molecular Biosciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (CISD1). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, COA of Formula: C15H22N2O2.
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