Yamane, Daisuke; Hayashi, Yuri; Matsumoto, Moe; Nakanishi, Hiroki; Imagawa, Haruka; Kohara, Michinori; Lemon, Stanley M.; Ichi, Ikuyo published the artcile< FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication>, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate, the main research area is HCV replication FADS fatty acid desaturation ferroptosis cellular sensitivity; FADS2; Mead acid; direct-acting antivirals; ferroptosis; hepatitis C virus; lipid peroxidation; polyunsaturated fatty acid.
The metabolic oxidative degradation of cellular lipids severely restricts replication of hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the factors regulating this process in infected cells. Here we show that HCV is restricted by an iron-dependent mechanism resembling the one triggering ferroptosis, an iron-dependent form of non-apoptotic cell death, and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2). Genetic depletion and ectopic expression experiments show FADS2 is a key determinant of cellular sensitivity to ferroptosis. Inhibiting FADS2 markedly enhances HCV replication, whereas the ferroptosis-inducing compound erastin alters conformation of the HCV replicase and sensitizes it to direct-acting antiviral agents targeting the viral protease. Our results identify FADS2 as a rate-limiting factor in ferroptosis, and suggest the possibility of pharmacol. manipulating the ferroptosis pathway to attenuate viral replication.
Cell Chemical Biology published new progress about Albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Safety of Ethyl 3-amino-4-(cyclohexylamino)benzoate.
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