Wen, Wandong; Young, Summer E.; Duvernay, Matthew T.; Schulte, Michael L.; Nance, Kellie D.; Melancon, Bruce J.; Engers, Julie; Locuson, Charles W.; Wood, Michael R.; Daniels, J. Scott; Wu, Wenjun; Lindsley, Craig W.; Hamm, Heidi E.; Stauffer, Shaun R. published the artcile< Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354>, Application of C19H34O2, the main research area is indole preparation protease activated receptor antagonist; ML354; PAR-4 antagonist; Protease activated receptor 4.
Herein the authors report the discovery and SAR of an indole-based protease activated receptor-4 (PAR-4) antagonist scaffold derived from a similarity search of the Vanderbilt HTS collection, leading to MLPCN probe ML354 I (VU0099704). Using a novel PAC-1 fluorescent αIIbβ3 activation assay this probe mol. antagonist was found to have an IC50 of 140 nM for PAR-4 with 71-fold selectivity vs. PAR-1 (IC50 = 10 μM).
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics