Thakur, Kratima; Khare, Naveen K. published the artcile< Synthesis of glycoconjugate mimics by 'click chemistry'>, HPLC of Formula: 4098-06-0, the main research area is click alkyne azide triazole cycloaddition catalyst preparation; triazole glycoconjugate preparation stereoselective library mol structure; 1,3-Dipolar cycloaddition; Click reaction; CuI; Glycoconjugates; Stereoselectivity.
Stereo-defined 2-deoxy propargyl glycosides can be used for the synthesis of corresponding 1,4-disubstituted sugar derived triazoles by using only CuI and stereo-defined sugar azide derivatives The click chem. which involves copper (I) catalyzed alkyne-azide 1,3-dipolar cycloaddition, was used to prepare a library of glycoconjugates mimics. Different sugar propargyl-2-deoxy-O-α-D-glycopyranoside derivatives and β-glycopyranosyl azide derivatives were coupled using catalyst CuI to yield triazole glycoconjugates. The catalyst CuI (2.5 equivalent) in CH3CN was found to be most efficient for the synthesis of 1,4-disubstituted triazole scaffolds affording up to 94% of optimized yield and with retention of the anomeric configuration of the starting glycosides. The key feature of this methodol. is the absence of sodium L-ascorbate/ascorbic acid which is most active substrate of current research with strong potential for click reactions. In this article, the library of novel stereoselective deoxy sugar derived triazole glycoconjugates have been synthesized and structures were determined by the 1H, 13C & 2D NMR spectroscopy.
Carbohydrate Research published new progress about 1,3-Dipolar cycloaddition reaction. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, HPLC of Formula: 4098-06-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics