Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection>, Electric Literature of 30095-98-8, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus.
A new series of 3,3′-spirocyclic 2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h, which exhibited excellent in vitro potency with an EC50 value of 0.8 nM and demonstrated 71% oral bioavailability in mice. In a mouse challenge model of RVS infection, 14h demonstrated superior efficacy with a 3.9log RSV virus load reduction in the lung following an oral dose of 50 mg/kg.
ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics