Schleicher, Kristin D.; Jamison, Timothy F. published the artcile< A reductive coupling strategy towards ripostatin A>, COA of Formula: C6H10O5, the main research area is ripostatin A synthesis reductive coupling enyne epoxide; catalysis; natural product; nickel; reductive coupling; ripostatin A; synthesis.
Synthetic studies on the antibiotic natural product ripostatin A have been carried out with the aim to construct the C9-C10 bond by a nickel(0)-catalyzed coupling reaction of an enyne and an epoxide, followed by rearrangement of the resulting dienylcyclopropane intermediate to afford the skipped 1,4,7-triene. A cyclopropyl enyne fragment, I, corresponding to C1-C9 has been synthesized in high yield and demonstrated to be a competent substrate for the nickel(0)-catalyzed coupling with a model epoxide. Several synthetic approaches toward the C10-C26 epoxide have been pursued. The C13 stereocenter can be set by allylation and reductive decyanation of a cyanohydrin acetonide. A mild, fluoride-promoted decarboxylation enables construction of the C15-C16 bond by an aldol reaction. The product of this transformation, ketone II, is of the correct oxidation state and potentially three steps removed from the targeted epoxide fragment.
Beilstein Journal of Organic Chemistry published new progress about Reductive coupling reaction. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, COA of Formula: C6H10O5.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics