Qiao, Zhi; Fu, Wen; Zhang, Yongchao; Chen, Ruijia; Xu, Zhiping; Li, Zhong; Shao, Xusheng published the artcile< Azobenzene-Semicarbazone Enables Optical Control of Insect Sodium Channels and Behavior>, HPLC of Formula: 2557-13-3, the main research area is azobenzene semicarbazone optical photoswitching sodium channel insect behavior; invertebrates; metaflumizone; photopharmacology; photoswitches; sodium channels.
Photopharmacol. uses mol. photoswitches to establish control over the action of bioactive mols. The application of photopharmacol. in the research of invertebrate sodium channels has not been investigated. Here we report several photochromic ligands of metaflumizone. One ligand, termed ABM04 (I), underwent reversible trans-cis isomerization under UV or blue light irradiation cis-ABM04 had excellent larvicidal activity against mosquito larvae with an LC50 value of 4.39 μM and showed insecticidal activity against Mythimna separata with an LC50 value of 7.19 μM. However, trans-ABM04 was not found to have biol. activity. ABM04 (10 μM) can induce depolarization of dorsal unpaired median neurons and enable the real-time photoregulation of mosquito larval behavior. The precise regulation of invertebrate sodium channels is realized for the first time, which provides a new strategy for the basic and accurate research of invertebrate sodium channels.
Journal of Agricultural and Food Chemistry published new progress about Aedes albopictus. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, HPLC of Formula: 2557-13-3.
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