Marchalin, Stefan; Chudik, Miloslav; Cvopova, Katarina; Kozisek, Jozef; Lesko, Jan; Daich, Adam published the artcile< Conformationally constrained 1,4-DHPs. A convenient route to bis-1,4-DHPs as a novel class of nitrogen compounds>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is pyridine dihydro preparation tandem Knoevenagel condensation aminonitrile cyclization; indolizine preparation; dihydropyridine bis preparation; active methylene compound dihydropyridine Knoevenagel condensation aminonitrile cyclization.
On heating in glacial AcOH, 2-formyl-1,4-dihydropyridines I (R1 = MeCO, Me2CHO2C; R2 = 3-O2NC6H4, 5-nitro-2-furyl) underwent the tandem Knoevenagel condensation/aminonitrile cyclization with activated methylene reagents, such as Me acetoacetate or benzoylacetonitrile, to afford highly functionalized indolizines II (R3 = CN, MeO2C) in 65-88% yields. However, treatment of I (R1 = CN, MeCO, MeO2C, Me2CHO2C; R2 = 3-O2NC6H4, 5-cyano-2-furyl, 2-thienyl, etc.) with 3-aminocrotonitrile gave the Knoevenagel condensation products, bis-1,4-dihydropyridines III, as the major products in 50-82% yields.
Tetrahedron published new progress about Crystal structure. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics