Loro, Camilla; Molteni, Letizia; Papis, Marta; Lo Presti, Leonardo; Foschi, Francesca; Beccalli, Egle M.; Broggini, Gianluigi published the artcile< Non-Decarboxylative Ruthenium-Catalyzed Rearrangement of 4-Alkylidene-isoxazol-5-ones to Pyrazole- and Isoxazole-4-carboxylic Acids>, Safety of Ethyl 3-oxo-3-phenylpropanoate, the main research area is pyrazole carboxylic acid preparation; hydroaminoalkylidenyl isoxazolone rearrangement ruthenium catalyst; isoxazole carboxylic acid preparation; hydroxyalkylidenyl isoxazolone rearrangement ruthenium catalyst.
Non-decarboxylative ruthenium-catalyzed rearrangement of 4-(2-hydroaminoalkylidenyl)- and 4-(2-hydroxyalkylidenyl)-substituted isoxazol-5(4H)-ones with catalytic amounts of [RuCl2(p-cymene)]2, without any additive, afforded pyrazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Et, etc.; R3 = Ph, CH2Bn, etc.] and isoxazole-4-carboxylic acids I [R1 = Me, Pr, Ph, etc.; R2 = H, Me, Ph, etc.] resp. The presence of an intramol. H-bond in these substrates was the key to divert the classical mechanism toward a ring-opening non-decarboxylative path that was expected to generate a vinyl Ru-nitrenoid intermediate, the cyclization of which afforded the rearranged products I and II. A gram scale protocol demonstrated the synthetic applicability of this transformation.
Organic Letters published new progress about Alkylidenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Safety of Ethyl 3-oxo-3-phenylpropanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics