Xing, Shuya; Zhu, Yu-Yi; Liu, Wen; Liu, Yong; Zhang, Jing; Zhang, Huarong; Wang, Yan; Ni, Shao-Fei; Shao, Xinxin published the artcile< C-H Fluoroalkylsulfinylation/Intramolecular Rearrangement for Precise Synthesis of Fluoroalkyl Sulfoxides>, Computed Properties of 30095-98-8, the main research area is fluoroalkyl sulfoxide preparation; arylhydroxylamine fluoroalkylsulfinylation intramol rearrangement.
An efficient methodol. to access various fluoroalkyl sulfoxides bearing ortho/para-functionalized amine scaffolds, e.g. I from arylhydroxylamines was described. The transformation was featured with new electrophilic trifluoromethylthiolated reagents, good functional group tolerance, and late-stage modification of complex bioactive scaffolds, providing a rapid access to prepare numerous trifluoromethyl- and difluoromethyl-substituted sulfoxides. Mechanism studies and d. functional theory calculations suggest this reaction goes through a nucleophilic trifluoromethylthiolation of arylhydroxylamine and subsequent internal 2,3-sigmatropic rearrangement involving a sulfur and oxygen transfer process.
Organic Letters published new progress about Hydroxylamines Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Computed Properties of 30095-98-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics