Uvyn, Annemiek; De Coen, Ruben; Gruijs, Mandy; Tuk, Cees W.; De Vrieze, Jana; van Egmond, Marjolein; De Geest, Bruno G. published the artcile< Efficient Innate Immune Killing of Cancer Cells Triggered by Cell Surface Anchoring of Multivalent Antibody-Recruiting Polymers>, Category: esters-buliding-blocks, the main research area is multivalent antibody recruiting polymer cancer cytolysis macrophage phagocytosis; antibodies; cancer; immune therapy; multivalency; polymer amphiphiles.
Binding of monoclonal antibodies (mAbs) onto a cell surface triggers antibody-mediated effector killing by innate immune cells through complement activation. As an alternative to mAbs, synthetic systems that can recruit endogenous antibodies from the blood stream to a cancer cell surface could be of great relevance. Herein, we explore antibody-recruiting polymers (ARPs) as a novel class of immunotherapy. ARPs consist of a cell-binding motif linked to a polymer that contains multiple small mol. antibody-binding motifs along its backbone. As a proof of concept, we employ a lipid anchor that inserts into the phospholipid cell membrane and make use of a polymeric activated ester scaffold onto which we substitute dinitrophenol as an antibody-binding motif. We demonstrate that ARPs allow for high avidity antibody binding and drive antibody recruitment to treated cells for several days. Furthermore, we show that ARP-treated cancer cells are prone to antibody-mediated killing through phagocytosis by macrophages.
Angewandte Chemie, International Edition published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics