Tsuboi, Ririko; Kitagawa, Haruaki; Imazato, Satoshi published the artcile< FGF-2 release and bonding/physical properties of 4-META/MMA-based adhesive resins incorporating small FGF-2-loaded polymer particles>, Formula: C18H26O6, the main research area is adhesive resin incorporating small FGF loaded polymer particle; Adhesive resin; FGF-2; Mechanical property; Osteoblast-like cell; polyHEMA/TMPT.
Non-biodegradable particles comprising hydroxyethyl methacrylate (HEMA) and trimethylolpropane trimethacrylate (TMPT) have been reported as useful carriers for fibroblast growth factor-2 (FGF-2). They have also been successfully incorporated into the 4-[2-(methacryloyloxy)ethoxycarbonyl]phthalic anhydride/methyl methacrylate-tri-Bu borane (4-META/MMA-TBB) resin to promote tissue regeneration. However, smaller particles are required to obtain restorative materials acceptable for clin. use. The aim of this study was to investigate the ability of the 4-META/MMA-TBB resin that comprises small FGF-2-loaded particles to release FGF-2 and promote cell proliferation. In addition, the bonding and phys. properties of the exptl. resin were evaluated.The small particles loaded with FGF-2 were newly fabricated and incorporated into the com. 4-META/MMA-TBB resin. Release profiles of FGF-2 from the exptl. resins were assessed, and the cell proliferation cultured with the eluate was evaluated. The bonding and phys. properties of the resins were evaluated using shear bond strength and three-point bending tests, and by measuring the curing time, water absorption, and water dissolutionSustained release of FGF-2 from the exptl. resins for two weeks was observed, and the released FGF-2 was demonstrated to promote cell proliferation. All bonding and phys. properties of the 4-META/MMA-TBB resins were found acceptable for clin. use.The small FGF-2-loaded particles incorporated into the 4-META/MMA-TBB resin had the same abilities to release FGF-2 and proliferate cells, as those exhibited by the conventionally sized particles. In addition, there were no adverse influences on bonding and phys. properties, suggesting that the bioactive adhesive resin was acceptable for clin. use.
Dental Materials published new progress about Absorption. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Formula: C18H26O6.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics