Tenti, Giammarco; Cores, Angel; Ramos, Maria Teresa; Menendez, J. Carlos published the artcile< (E)-3-((2-fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is imidazopyridinone methylene hydroxy fluorophenyl preparation diastereoselective; pyridyl bromine ketoamide domino bromination cyclization tautomerism.
Treatment of a 3-(2-fluorophenyl)-3-oxo-N-(pyridin-2-yl)propanamide precursor with bromine afforded the first example of the (E)-3-((2-fluorophenyl)(hydroxy)methylene)imidazo[1,2-a]pyridin-2(3H)-one framework. This transformation proceeded through a domino process comprising an initial bromination, cyclization via an intramol. SN reaction, and a final keto-enol tautomerism, and allows generation of the fused heterocyclic system and installation of the acyl substituent in a single operation.
Molbank published new progress about Bromination. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics