Pirrung, Michael C.; Liu, Yufa; Deng, Liu; Halstead, Diana K.; Li, Zhitao; May, John F.; Wedel, Michael; Austin, Darrell A.; Webster, Nicholas J. G. published the artcile< Methyl Scanning: Total Synthesis of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptor(s)>, Quality Control of 112-63-0, the main research area is demethylasterriquinone B1 derivative preparation; methyl scanning demethylasterriquinone B1 derivative insulin receptor binding.
The principle of Me scanning is proposed for determination of the sites of interaction between biol. active small mols. and their macromol. target(s). It involves the systematic preparation of a family of methylated derivatives of a compound and their biol. testing. As a functional assay, the method can identify the regions of a mol. that are important (and unimportant) for biol. activity against even unknown targets, and thus provides an excellent complement to structural biol. Me scanning was applied to demethylasterriquinone B1, a small-mol. mimetic of insulin. A new, optimal total synthesis of this natural product was developed that enables the family of Me scan derivatives to be concisely prepared for evaluation in a cellular assay. The results of this experiment were used to design a biotin-demethylasterriquinone conjugate for use as an affinity reagent. This compound was prepared in tens of milligram quantities in a four-step synthesis.
Journal of the American Chemical Society published new progress about Insulin receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics