Lee, Joyce H.; Mosher, Eric P.; Lee, Young-Sam; Bumpus, Namandje N.; Berger, James M. published the artcile< Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is topoisomerase chemotherapeutic inhibition TCA cycle metabolite; DNA topology; ICRF-187; TCA cycle; cancer; chemotherapy; dexrazoxane; etoposide; metabolism; topoisomerase.
Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the phys. passage of one duplex through another and depends on the transient formation of double-stranded DNA breaks, a step exploited by frontline chemotherapeutics to kill cancer cells. Although anti-topo II drugs are efficacious, they also elicit cytotoxic side effects in normal cells; insights into how topo II is regulated in different cellular contexts is essential to improve their targeted use. Using chem. fractionation and mass spectrometry, we have discovered that topo II is subject to metabolic control through the TCA cycle. We show that TCA metabolites stimulate topo II activity in vitro and that levels of TCA flux modulate cellular sensitivity to anti-topo II drugs in vivo. Our work reveals an unanticipated connection between the control of DNA topol. and cellular metabolism, a finding with ramifications for the clin. use of anti-topo II therapies.
Cell Chemical Biology published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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Ester – an overview | ScienceDirect Topics