Kim, DaWon; Lee, Jeong Hwa; Kim, Hye Yun; Shin, Jisu; Kim, Kyeonghwan; Lee, Sejin; Park, Jinwoo; Kim, JinIkyon; Kim, YoungSoo published the artcile< Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model>, Application of C8H9NO3, the main research area is alzheimer disease brain amyloid beta.
Alzheimer disease (AD) is a neurodegenerative disorder characterized by the aberrant production and accumulation of amyloid-β (Aβ) peptides in the brain. Accumulated Aβ in soluble oligomer and insoluble plaque forms are considered to be a pathol. culprit and biomarker of the disorder. Here, we report a fluorescent universal Aβ-indicator YI-13, 5-(4-fluorobenzoyl)-7,8-dihydropyrrolo[1,2-b]isoquinolin-9(6H)-one, which detects Aβ monomers, dimers, and plaques. We synthesized a library of 26 fluorescence chems. with the indolizine core and screen them through a series of in vitro tests utilizing Aβ as a target and YI-13 was selected as the final imaging candidate. YI-13 was found to stain and visualize insoluble Aβ plaques in the brain tissue, of a transgenic mouse model with five familial AD mutations (5XFAD), by a histochem. approach and to label soluble Aβ oligomers within brain lysates of the mouse model under a fluorescence plate reader. Among oligomers aggregated from monomers and synthetic dimers from chem. conjugated monomers, YI-13 preferred the dimeric Aβ.
PLoS One published new progress about Alzheimer disease. 7126-50-3 belongs to class esters-buliding-blocks, and the molecular formula is C8H9NO3, Application of C8H9NO3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics