Huang, Xiaohua; Cheng, Cliff C.; Fischmann, Thierry O.; Duca, Jose S.; Yang, Xianshu; Richards, Matthew; Shipps, Gerald W. published the artcile< Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is thiazole carboxamidophenyl piperazine preparation CHK1 kinase inhibitor SAR; Automated Ligand Identification System (ALIS); CHK1 protein kinase; affinity selection−mass spectrometry (AS-MS); structure-based drug design; thiazole-4-carboxamide.
A novel series of CHK1 inhibitors with a distinctive hinge binding mode, exemplified by 2-aryl-N-(2-(piperazin-1-yl)phenyl)thiazole-4-carboxamide, was discovered through high-throughput screening using the affinity selection-mass spectrometry (AS-MS)-based Automated Ligand Identification System (ALIS) platform. Structure-based ligand design and optimization led to significant improvements in potency to the single digit nanomolar range and hundred-fold selectivity against CDK2.
ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics