Hu, Longqin’s team published research in Bioorganic & Medicinal Chemistry Letters in 2000-04-17 | 30095-98-8

Bioorganic & Medicinal Chemistry Letters published new progress about Prodrugs. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Hu, Longqin; Liu, Bin; Hacking, Douglas R. published the artcile< 5'-[2-(2-Nitrophenyl)-2-methylpropionyl]-2'-deoxy-5-fluorouridine as a potential bioreductively activated prodrug of FUDR: synthesis, stability and reductive activation>, COA of Formula: C9H9NO4, the main research area is nitrophenylmethylpropionyl deoxyfluorouridine preparation FUDR prodrug; anticancer FUDR reductive activation nitrophenylmethylpropionyl deoxyfluorouridine.

5′-[2-(2-Nitrophenyl)-2-methylpropionyl]-2′-deoxy-5-fluorouridine was synthesized as a potential bioreductively activated prodrug of 5-fluoro-2′-deoxyuridine (FUDR). The target compound was stable in both phosphate buffer and human serum and was found to release quickly the parent drug FUDR in quant. yield upon mild chem. reduction

Bioorganic & Medicinal Chemistry Letters published new progress about Prodrugs. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, COA of Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics