Li, Yang; Beija, Mariana; Laurent, Sophie; vander Elst, Luce; Muller, Robert N.; Duong, Hien T. T.; Lowe, Andrew B.; Davis, Thomas P.; Boyer, Cyrille published the artcile< Macromolecular Ligands for Gadolinium MRI Contrast Agents>, Application In Synthesis of 71195-85-2, the main research area is fluoropolymer gadolinium MRI contrast agent preparation.
Macromol. ligands for gadolinium contrast agents (CAs) were prepared via a grafting to strategy. Copolymers of oligoethylene glycol Me ether acrylate (OEGA) and an activated ester monomer, pentafluorophenyl acrylate (PFPA), were synthesized and modified with the 1-(5-amino-3-aza-2-oxypentyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (DO3A-tBu-NH2) chelate for the complexation of Gd3+. The relaxivity properties of the ligated Gd3+ agents were then studied to evaluate the effect of macromol. architecture on their behavior as magnetic resonance imaging (MRI) CAs. Ligands made from linear and hyperbranched macromols. showed a substantially increased relaxivity in comparison to existing com. Gd3+ MRI contrast agents. In contrast, star nanogel polymers exhibited a slightly lower relaxivity per Gd3+ ion (but still substantially higher relaxivity than existing low mol. weight com. CAs). This work shows that macromol. ligands have the potential to serve as components of Gd MRI agents as there are enhanced effects on relaxivity, allowing for lower Gd concentrations to achieve contrast, while potentially imparting control over pharmacokinetics.
Macromolecules (Washington, DC, United States) published new progress about Cytotoxicity. 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Application In Synthesis of 71195-85-2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics