Jimenez-Morales, Jose Marcos; Hernandez-Cuenca, Yanet Elisa; Reyes-Abrahantes, Ander; Ruiz-Garcia, Henry; Barajas-Olmos, Francisco; Garcia-Ortiz, Humberto; Orozco, Lorena; Quinones-Hinojosa, Alfredo; Reyes-Gonzalez, Jesus; Abrahantes-Perez, Maria del Carmen published the artcile< MicroRNA delivery systems in glioma therapy and perspectives: A systematic review>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is review glioma microRNA delivery systems antitumor lipid nanoparticles; Drug delivery system; Glioma; MicroRNAs; Molecular targeted therapy; Translational medicine.
A review. Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clin. armamentarium. This systemic review evaluates current mol. and pre-clin. studies with the aim of defining the most appealing supramol. platform for administering therapeutic miRNA to patients with gliomas. An integrated anal. suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramol. platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) mols. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of mols. as active ingredients. Further exptl. validation is warranted to confirm the practical value of miRNA delivery systems.
Journal of Controlled Release published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics