Yang, Zan; Cao, Ting; Liu, Si; Li, An; Liu, Kun; Yang, Tao; Zhou, Congshan published the artcile< Transition-metal-free S-N bond formation: synthesis of 5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines>, Application In Synthesis of 19241-24-8, the main research area is thiadiazole amino preparation regioselective green chem; amidine isothiocyanate tandem radical oxidative cyclization.
A novel and green method for the synthesis of 5-amino-1,2,4-thiadiazoles I (R1 = Me, cyclopropyl, 4-fluorophenyl, pyridin-3-yl, 1H-pyrazol-1-yl, etc.; R2 = tert-Bu, benzyl, naphth-1-yl, etc.) has been developed by the reaction of isothiocyanates R2N=C=S with amidines R1C(=NH)NH2.HCl. This protocol which is free of metal, catalyst and iodine involves O2 oxidative S-N bond formation for the synthesis of various 5-amino-1,2,4-thiadiazole derivatives I with excellent to good yields. High regioselectivity, mild reaction conditions, broad substrate scope and good functional group tolerance are the highlights of the report.
New Journal of Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Application In Synthesis of 19241-24-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics