More, Swati S.; Vince, Robert published the artcile< Inhibition of Glyoxalase I: The First Low-Nanomolar Tight-Binding Inhibitors>, Reference of 77215-54-4, the main research area is glutathione based peptide hydroxamate preparation low nanomolar inhibitor glyoxalase.
A series of rational modifications to the structure of known S-(N-aryl-N-hydroxycarbamoyl)glutathione-based glyoxalase I inhibitors culminated in the discovery of the first single-digit nanomolar inhibitor. This study makes available key information about possible means to address the issues of metabolic instability, low potency, and synthetic complexity that have plagued the area of glyoxalase I inhibition. Knowledge garnered from this study has implications in the design of inhibitors with higher conformational definition and lower peptidic character.
Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 77215-54-4 belongs to class esters-buliding-blocks, and the molecular formula is C12H24N2O4, Reference of 77215-54-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics