Liang, Xianyu; Liu, Fan; Wan, Yiqun; Yin, Xiaoying; Liu, Weiting published the artcile< Facile synthesis of molecularly imprinted polymers for selective extraction of tyrosine metabolites in human urine>, Electric Literature of 3290-92-4, the main research area is molecularly imprinted polymer tyrosine metabolite extraction urine; Human urine; Molecular imprinted polymer; Selective extraction; Tyrosine metabolites; Ultra-high performance liquid chromatography.
In this study a method is developed for quant. anal. of three potential biomarkers, including 4-hydroxyphenyl acetic acid (PHPAA), 4-hydroxyphenyl lactic acid (PHPLA) and 3,4-hydroxyphenylpropionic acid (PHPA), in human urine. Mol. imprinted polymers (MIPs) as the sample clean up materials were applied to selectively extract these tyrosine metabolites, followed by precise detection using ultra-high performance liquid chromatog. coupled with a fluorescence detector (UHPLC-FLD). The MIP was prepared by precipitation polymerization adopting PHPAA as the template mol., 1-vinylimidazole (1-vinyl) as functional monomer, trimethylolpropane triacrylate (TRIM) as crosslinker, 2-methylpropionitrile (AIBN) as initiator and acetonitrile as a porogen. The mol. recognition properties and selectivity of MIPs were systematically evaluated, of which results demonstrated high selectivity for three analytes in human urine. Parameters affecting the extraction efficiency were further optimized. Under the optimum conditions, the limits of detection of PHPAA, PHPLA, and PHPA were 1.8 × 10-4, 4.7 × 10-5 and 5.8 × 10-5 mmol L-1, resp., and the recoveries were in the range of 75.7%-110.3%. The method described here provided insights into the future development of materials for highly efficient and selective enrichment of targeted substances.
Journal of Chromatography A published new progress about Homo sapiens. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Electric Literature of 3290-92-4.
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