He, Yahui; Zeng, Shaomei; Abd El-Aty, A. M.; Hacimuftuoglu, Ahmet; Yohannes, Woldemariam Kalekristos; Khan, Majid; She, Yongxin published the artcile< Development of water-compatible molecularly imprinted polymers based on functionalized β-cyclodextrin for controlled release of atropine>, Product Details of C18H26O6, the main research area is atropine beta cyclodextrin water compatible molecularly imprinted polymer; Atropine; controlled release; molecularly imprinted polymers; water-compatible; β-cyclodextrin.
Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-β-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template mol. The effects of different compounds and concentrations of crosslinking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-β-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.
Polymers (Basel, Switzerland) published new progress about Drug delivery systems. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Product Details of C18H26O6.
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