Zhao, Xinhong; Sun, Chao; Zhao, Yanwu; Jin, Ying; Kang, Bingya; Chen, Tianchao published the artcile< Effects of different material ratios on the dissolution of Tongmai pills>, Reference of 112-63-0, the main research area is tongmai dissolution pill grease resin fiber.
To study the effects of different material ratios on the dissolution of Tongmai pills. Based on mixture uniform experiment design, the fiber, starch and grease-resin materials in Tongmai pills were proportioned. The contents of strychnine, brucine, paeoniflorin, calycosin, ferulic acid, hesperidin and salvianolic acid B in the solution were determined by HPLC, and the content of total flavonoids was determined by UV spectrophotometry. The weight coefficient of index components was determined by analytic hierarchy process, and the SAS software was used to optimize the dissolution model and calculate the dissolution parameter T40. MATLAB was used to establish a math. model and realize the data visualization between material ratio and dissolution parameter T40. The math. model between material ratio and dissolution parameter was T40 = 8.93 – 5.31X1 – 5.83X2 + 17.67X1X3 (X1, X2, X3 are fiber, starch and grease-resin materials resp., r2 = 0.970 6, P = 0.01, RMSE = 0.569 6). Fiber can effectively promote the dissolution (P < 0.05).Starch can promote the dissolution, but the effect is not obvious (P = 0.05). The interaction between fiber and grease-resin can inhibit the dissolution, but was not significant (P = 0.07). Medicinal Plant published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
Referemce:
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