Shimizu, Hiroaki; Yoshinaga, Kohei; Yokoshima, Satoshi published the artcile< Nitrone Formation by Reaction of an Enolate with a Nitro Group>, SDS of cas: 30095-98-8, the main research area is quinolinedione preparation dipolar cycloaddition; isoxazoloquinolinone preparation; base mediated cyclocondensation ketonitroarene mechanism transition state structure; intramol dipolar cycloaddition alkenyl isoxazoloquinolinone nitrone.
Ketones with a 2-nitrophenyl group at the α-position such as I were treated with sodium hydroxide in methanol at 60 °C. Under these conditions, enolates derived from the ketones intramolecularly reacted with the nitro group to form a variety of nitrones such as II. Addnl. exptl. results, including the unexpected isolation of N-hydroxyindolinone as a byproduct, led to a proposed reaction mechanism, occurring via an α-hydroxyketone. The resultant nitrones underwent inter- and intramol. 1,3-dipolar cycloaddition with olefins to afford polycyclic isoxazolidines such as III.
Organic Letters published new progress about 1,3-Dipolar cycloaddition reaction. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, SDS of cas: 30095-98-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics