Qiu, Xiaoguang; Chen, Yidong; Bao, Zhaoshi; Chen, Li; Jiang, Tao published the artcile< Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild-type and TERT promoter mutation WHO grade II/III gliomas: A prospective randomized study>, Reference of 112-63-0, the main research area is glioma temozolomide isocitrate dehydrogenase chemoradiotherapy radiotherapy mutation survival; Grade II/III glioma; IDH mutation; Radiotherapy; TERT promoter mutation; Temozolomide.
Patients with grade II/III diffuse glioma (lower grade glioma, LGG) with isocitrate dehydrogenase wild-type (IDH-wt) and telomerase reverse-transcriptase promoter mutation (TERTp-mut) experience shorter overall survival (OS) time than IDH mutant patients. The optimal treatment strategy for these patients is unclear. We compared the effects of radiotherapy (RT) alone vs. RT concurrent with temozolomide (TMZ) followed by adjuvant TMZ in these LGG patients.Thirty-seven LGG patients with IDH-wt and TERTp-mut were randomly allocated to either RT alone treatment (RT group, n = 18; 60 Gy in 30 daily fractions) or RT concurrent with TMZ (75 mg/m2/d, 7 d/wk) followed by adjuvant TMZ (CRT group, n = 19). The median follow-up duration was 17 mo. Log-rank test was used for OS and PFS comparisons.The 1-yr OS rate was 94.1[95confidence interval (CI) 82.9-100] in the CRT group and 74.6(95CI, 52.9-96.4) in the RT group. The median OS values in the CRT and RT groups were statistically different [25 vs. 17 mo, resp.; hazard ratio (HR) 0.271; 95CI, 0.092-0.793; P = 0.017], while PFS values were not (16 vs. 7 mo, resp.; HR, 0.917; 95CI, 0.397-2.120; P = 0.840). Multivariate anal. indicated that CRT treatment and female sex were associated with significantly longer OS (P = 0.001, P = 0.016, resp.).CRT treatment for IDH-wt/TERTp-mut grade II/III gliomas resulted in significantly longer OS than RT alone. Female sex was a significant favorable prognostic factor.
Radiotherapy and Oncology published new progress about Chemoradiotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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