Lucchetti, Nicola; Gilmour, Ryan published the artcile< Reengineering Chemical Glycosylation: Direct, Metal-Free Anomeric O-Arylation of Unactivated Carbohydrates>, COA of Formula: C12H16O7, the main research area is aryl glycoside preparation anomeric arylation unactivated lactol diaryliodonium salt; acetals; arylation; carbohydrates; fluorine; stereoretention.
To sustain innovation in glycobiol., effective routes to well-defined carbohydrate probes must be developed. For over a century, glycosylation has been dominated by the formation of the anomeric Csp3-O acetal junction in glycostructures. A dissociative mechanistic spectrum spanning SN1 and SN2 is frequently operational thereby reducing the efficiency. By reengineering this fundamental process, an orthogonal disconnection allows the acetal to be formed directly from the reducing sugar without the need for substrate pre-functionalization. The use of stable aryliodonium salts facilitates a formal O-H functionalization reaction. This allows lactols to undergo mild, metal-free O-arylation at ambient temperature The efficiency of the transformation has been validated using a variety of pyranoside and furanoside monosaccharides in addition to biol. relevant di- and trisaccharides (up to 85 %). Fluorinated mechanistic probes that augment the anomeric effect were employed. It is envisaged that this strategy will prove expansive for the construction of complex acetals under substrate-based stereocontrol.
Chemistry – A European Journal published new progress about Anomeric effect. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, COA of Formula: C12H16O7.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics