Im, Eun-Ju; Lee, Chan-Hyeong; Moon, Pyong-Gon; Rangaswamy, Gunassekaran Gowri; Lee, Byungheon; Lee, Jae Man; Lee, Jae-Chul; Jee, Jun-Goo; Bae, Jong-Sup; Kwon, Taeg-Kyu; Kang, Keon-Wook; Jeong, Myeong-Seon; Lee, Joo-Eun; Jung, Hyun-Suk; Ro, Hyun-Joo; Jun, Sangmi; Kang, Wonku; Seo, Seung-Yong; Cho, Young-Eun; Song, Byoung-Joon; Baek, Moon-Chang published the artcile< Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A>, Category: esters-buliding-blocks, the main research area is sulfisoxazole anticancer agent breast cancer metastasis.
Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biol. research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secretion from breast cancer cells through interference with endothelin receptor A (ETA). SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, the reduced expression of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multivesicular endosomes with lysosomes for degradation We demonstrate the important role of ETA, as target of SFX, by gain- and loss-of-function studies of the ETA protein, through a direct binding assay, and pharmacol. and genetic approaches. These findings may provide a foundation for sEV-targeted cancer therapies and the mechanistic studies on sEV biol.
Nature Communications published new progress about Animal gene, CCL2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics