Month: November 2022

Ye, Qiuji published the artcileStructure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists, COA of Formula: C9H8O4, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(20), 4770-4776, database is CAplus and MEDLINE.

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as I using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-Me compound It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.

Bioorganic & Medicinal Chemistry Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C16H24BF4Ir, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Meesin, Jatuporn published the artcileDimerization of 3-Chlorooxindoles Mediated by Potassium Ethylxanthate: Synthesis of Isoindigos, Application In Synthesis of 3052-61-7, the publication is Synlett (2022), 33(14), 1317-1322, database is CAplus.

A novel dimerization of 3-chlorooxindoles I (R¹ = H, 5-Br, 5-Me, 6-Cl, 7-F, etc., R² = H; R¹ = H, R² = Me, H₂C:CHCH₂, PhCH₂) promoted by potassium ethylxanthate to access isoindigo derivatives II is described. The reactions proceeded readily at room temperature in short reaction times. A mechanistic study revealed that the 3-chlorooxindole is initially converted into O-Et S-(2-oxo-2,3-dihydro-1 H-indol-3-yl) dithiocarbonate, which subsequently undergoes dimerization with elimination of carbon disulfide. In almost all cases, anal. pure isoindigos II were isolated in moderate to good yields without a requirement for chromatog. purification

Synlett published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Application In Synthesis of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kim, Jeehwan published the artcileEffect of dispersants on structural integrity of 3D printed ceramics, Quality Control of 15625-89-5, the publication is International Journal of Applied Ceramic Technology (2022), 19(2), 968-978, database is CAplus.

Ceramic 3D printing based on stereolithog. is an excellent alternative to overcome drawbacks of conventional subtractive manufacturing for 3D shape control. Optimization of photocurable ceramic slurry is one of the most essential conditions to achieve favorable 3D printed structures using SL. Homogeneity of ceramic particle dispersion in photocurable resin is particularly important to optimize ceramic suspension. Dispersant plays a significant role in increasing homogeneity. Dispersant in photocurable ceramic resin has an addnl. effect on photocurability and integrity of 3D printed green body. We herein discuss how dispersants influence 3D printing conditions based on stereolithog. using various com. available dispersants of BYK series such as BYK103, BYK111, BYK180, BYK182, and BYK2001. Both BYK111 and BYK180 showed better performances than others because of their lower volatilities under general temperature condition during a printing process. Both solubility and decomposition temperature of dispersants largely influenced the structural quality after washing and debinding processes. This study provides worthy information to design photocurable ceramic suspension for various types of ceramic materials.

International Journal of Applied Ceramic Technology published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C15H20O6, Quality Control of 15625-89-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lim, Hyun-Hee published the artcileFlavor components in tobacco capsules identified through non-targeted quantitative analysis, SDS of cas: 103-26-4, the publication is Journal of Mass Spectrometry (2022), 57(2), e4811, database is CAplus and MEDLINE.

Tobacco flavors increase the attractiveness of a tobacco brand and ultimately promote addiction. Information about what flavor and how much flavor is in flavor capsules can provide an effective way to regulate tobacco flavor. In this study, 128 flavor chems. were identified and quantified by gas chromatog.-mass spectrometry using libraries and authentic standards Validation of the developed method was performed for interference, detection limits, calibration curves, accuracy, and precision. Menthol was the main ingredient in all capsules, and the carcinogenic pulegone was detected. Detected menthofuran, benzyl alc., geraniol, and eugenol cause toxic or severe irritation, and detected lactones can increase nicotine addiction by inhibiting nicotine metabolism in smokers. Margin of exposures for carcinogenic pulegone and non-carcinogenic menthol were well below safety thresholds, indicating a significant risk of inhalation exposure. It is desirable to prohibit the use of flavor capsules in consideration of human risk.

Journal of Mass Spectrometry published new progress about 103-26-4. 103-26-4 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Benzene,Ester,Protease,Tyrosinase,Natural product, name is Methyl 3-phenyl-2-propenoate, and the molecular formula is C10H10O2, SDS of cas: 103-26-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Choi, E-Joon published the artcileDimesogenic compounds with chiral tails. Synthesis and liquid crystalline properties of a homologous series of α,ω-bis[4-(4′-(S)-(-)-2-methylbutoxycarbonyl-biphenyl-4-oxycarbonyl)phenoxy]alkanes, COA of Formula: C15H14O3, the publication is Bulletin of the Korean Chemical Society (2000), 21(1), 110-117, database is CAplus.

A series of new liquid crystalline dimesogenic compounds with chiral tails was synthesized, and their thermal and liquid crystalline properties were studied. The chain length of the central polymethylene spacers (x) was varied from dimethylene (2) to decamethylene (12). These compounds were characterized by elemental anal., IR and NMR spectroscopy, differential scanning calorimetry (DSC), and cross-polarizing microscopy. All compounds were found to be enantiotropically liquid crystalline, and the values of melting (T_m) and isotropization temperature (T_i) as well as enthalpy change (ΔH_i) and entropy change for isotropization (ΔS_i) decreased in a zig-zag fashion revealing the so-called odd-even effect as x increases. Their mesomorphic properties fall into 3 categories depending upon x; (a) compounds with x = 2 and 4 formed two different mesophases, smectic and cholesteric phases in that order on heating, and vice versa on cooling, (b) compounds with x = 3, 7, 8, 10, and 11 reversibly formed only the cholesteric phase, and (c) compounds with x = 5, 6, 9, and 12 exhibited only a cholesteric phase on heating, whereas on cooling they formed 2 different mesophases, cholesteric and smectic phases, sequentially.

Bulletin of the Korean Chemical Society published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, COA of Formula: C15H14O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Myongsoo published the artcileHydrogen-Bonding-Mediated Formation of Supramolecular Rod-Coil Copolymers Exhibiting Hexagonal Columnar and Bicontinuous Cubic Liquid Crystalline Assemblies, HPLC of Formula: 50670-76-3, the publication is Macromolecules (1999), 32(25), 8531-8537, database is CAplus.

The preparation and characterization of the supramol. rod-coil copolymers directed by mol. recognition of 4,4′-bipyridine and 4-[poly(propyleneoxy)propyloxy]-4′-bis(biphenyl carboxylic acid) with d.p. of poly(propylene oxide) coil of eight (P-8-HP), 10 (P-10-HP), 15 (P-15-HP), 17 (P-17-HP), 21 (P-21-HP), 27 (P-27-HP) and 34 (P-34-HP) are described. The introduction of poly(propylene oxide) (PPO) coils with different lengths into the rodlike polymeric system induces a rich variety of self-assembled microstructures. In the crystalline phase, the supramol. rod-coil copolymers with DP of PPO 8-17 organize into a microphase-separated monolayer lamellar structure. In contrast, the supramol. rod-coil copolymers with DP of PPO 21-34 exhibit a hexagonal columnar crystalline phase. A dramatic phase change after crystalline melting of the polymers is observed with the variation of the coil length. The supramol. rod-coil copolymers P-8-HP and P-10-HP display a bicontinuous cubic mesophase with Ia3d symmetry, while the supramol. rod-coil copolymers P-15-HP, P-17-HP, and P-21-HP with a medium length of PPO coil exhibit a hexagonal columnar mesophase. Further increasing the length of coil, as in the case of P-27-HP and P-34-HP, suppresses liquid crystallinity and induces only crystalline polymers.

Macromolecules published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, HPLC of Formula: 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Myongsoo published the artcileInduction of Thermotropic Liquid Crystalline Phases in Coil-Rod-Coil Triblock Molecules Containing Poly(propylene oxide) through Complexation with LiCF₃SO₃, Synthetic Route of 50670-76-3, the publication is Chemistry of Materials (1998), 10(7), 1894-1903, database is CAplus.

The preparation and thermotropic phase behavior of coil-rod-coil triblock mols. of dodecyl 4-(4-oxy-4′-biphenylcarbonyloxy)-4′-biphenylcarboxylate with poly(propylene oxide) of seven (7-22) and twelve (12-22) propylene oxide subunits and the complexes of the triblock mols. with LiCF₃SO₃ are presented. Both 7-22 and 12-22 appear to be crystalline solids. However, the complexation of 7-22 and 12-22 with LiCF₃SO₃ induces an enantiotropic liquid crystalline phase. The complexes of 7-22 with 0.05-0.20 mol of LiCF₃SO₃ per propylene oxide unit exhibit an enantiotropic smectic A mesophase. In contrast, a significant phase change is observed upon complexation of 12-22 with LiCF₃SO₃. The complex of 12-22 with 0.10 mol of LiCF₃SO₃ exhibits a smectic A mesophase. However, the complexes with 0.15-0.30 mol of LiCF₃SO₃ display a hexagonal columnar mesophase. The thermal stability of the mesophase exhibited by the Li complexes based on each triblock mol. increases with increasing salt concentration This behavior is attributed to the dynamics of ionic association resulting from specific interactions between the ether oxygens and the cations. These results, characterized by a combination of techniques consisting of differential scanning calorimetry, thermal optical microscopy, and Raman spectroscopy, are discussed.

Chemistry of Materials published new progress about 50670-76-3. 50670-76-3 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester, name is Ethyl 4′-hydroxy-[1,1′-biphenyl]-4-carboxylate, and the molecular formula is C15H14O3, Synthetic Route of 50670-76-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bonini, C. published the artcileSynthesis and biological evaluation of new simple indolic non peptidic HIV Protease inhibitors: The effect of different substitution patterns, Name: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, the publication is Bioorganic & Medicinal Chemistry (2014), 22(17), 4792-4802, database is CAplus and MEDLINE.

New structurally simple indolic non peptidic HIV Protease inhibitors were synthesized from (S)-glycidol by regioselective methods. Following the concept of targeting the protein backbone, different substitution patterns were introduced onto the common stereo-defined isopropanolamine core modifying the type of functional group on the indole, the position of the functional group on the indole and the type of the nitrogen containing group (sulfonamides or perhydroisoquinoline), alternatively. The systematic study on in vitro inhibition activity of such compounds confirmed the general beneficial effect of the 5-indolyl substituents in presence of arylsulfonamide moieties, which furnished activities in the micromolar range. Preliminary docking anal. allowed to identify several key features of the binding mode of such compounds to the protease.

Bioorganic & Medicinal Chemistry published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Name: (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ashokkumar, Veeramanoharan published the artcileBinaphthyl-based chiral bifunctional organocatalysts for water mediated asymmetric List-Lerner-Barbas aldol reactions, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), the publication is Organic & Biomolecular Chemistry (2016), 14(38), 9021-9032, database is CAplus and MEDLINE.

Binaphthyl-based chiral bifunctional organocatalysts were designed, synthesized and successfully applied to the asym. List-Lerner-Barbas aldol reaction in the presence of water. These organocatalysts were found to be effective catalysts for the reactions of sym., unsym. and cyclic ketones with different aldehydes to give the corresponding aldol products with higher yields (up to 98%) and very good ee’s up to 99%. The catalytic system leads to higher yields and selectivities than the previously reported well-known proline based organocatalysts. In addition to the effect of solvent, additives, catalyst concentration, temperature and the substrate scope of the reactions were also investigated.

Organic & Biomolecular Chemistry published new progress about 126613-06-7. 126613-06-7 belongs to esters-buliding-blocks, auxiliary class Chiral Diphenols, name is (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate), and the molecular formula is C22H12F6O6S2, Name: (R)-[1,1′-Binaphthalene]-2,2′-diyl bis(trifluoromethanesulfonate).

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reed, D. W. published the artcileField trapping of three Epinotia species with (Z,Z)-7,9-dodecadienyl acetate (Lepidoptera: Tortricidae), SDS of cas: 16974-11-1, the publication is Journal of Chemical Ecology (1985), 11(10), 1389-98, database is CAplus and MEDLINE.

A field survey of the geometrical isomers of 7,9-dodecadienyl alc., acetate, and aldehyde has resulted in attractants and inhibitors for 3 species of tortricid moths. Epinotia silvertoniensis And an undescribed Epinotia species were all attracted to (Z,Z)-7,9-dodecadienyl acetate. Another Epinotia species was attracted to (Z,Z)-7,9-dodecadienyl acetate and (Z,Z)-7,9-dodecadien-1-ol. Electroantennogram data and inhibition patterns for one of the Epinotia species were also reported. In addition, E. criddleana was attracted to lures containing (E)-9-dodecenyl acetate.

Journal of Chemical Ecology published new progress about 16974-11-1. 16974-11-1 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is (Z)-Dodec-9-en-1-yl acetate, and the molecular formula is C14H26O2, SDS of cas: 16974-11-1.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics