Month: October 2022

Fobi, Kwabena; Bunce, Richard A. published the artcile< Domino Nitro Reduction-Friedlander Heterocyclization for the Preparation of Quinolines>, Name: Ethyl 3-oxo-3-phenylpropanoate, the main research area is quinoline preparation; aminobenzaldehyde activated ketone domino nitro reduction Friedlander heterocyclization; Friedländer synthesis; dissolving metal reduction; domino reaction; heterocyclization; quinolin-2(1H)-ones; quinolines.

The Friedlander synthesis offers efficient access to substituted quinolines from 2-aminobenzaldehydes and activated ketones in the presence of a base. The disadvantage of this procedure lies in the fact that relatively few 2-aminobenzaldehyde derivatives are readily available. To overcome this problem, authors report a modification of this process involving the in situ reduction of 2-nitrobenzaldehydes with Fe/AcOH in the presence of active methylene compounds (AMCs) to produce substituted quinolines in high yields. The conditions are mild enough to tolerate a wide range of functionality in both reacting partners and promote reactions not only with Ph and benzyl ketones, but also with β-keto-esters, β-keto-nitriles, β-keto-sulfones and β-diketones. The reaction of 2-nitroarom. ketones with unsym. AMCs is less reliable, giving a competitive formation of substituted quinolin-2(1H)-ones from the cyclization of the Z Knoevenagel intermediate which appears to be favored when certain large groups are adjacent to the AMC ketone carbonyl.

Molecules published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Name: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Chunyu; Tian, Xianhai; Song, Lina; Liu, Yaowen; Hashmi, A. Stephen K. published the artcile< Tetra-substituted furans by a gold-catalysed tandem C(sp3)-H alkynylation/oxy-alkynylation reaction>, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate, the main research area is THF preparation; ketone hypervalent iodine reagent tandem alkynylation oxyalkynylation.

A gold-catalyzed cascade C(sp3)-H alkynylation/oxy-alkynylation of acceptor-substituted carbonyl compounds with hypervalent iodine(III) reagents for the synthesis of tetra-substituted furans is described. This reaction involves two Au(I)/Au(III) catalytic cycles and proceeds through a C(sp3)-H alkynylation of a substituted ketone and a subsequent oxy-alkynylation of the generated 2-alkynyl ketone. This mild and simple method can tolerate a wide range of functionalities, offering distinct advantages over previous methods using PIDA as the external oxidant. Furthermore, a gram-scale synthesis is feasible and the synthesized furan product was readily transformed into other related compounds

Organic Chemistry Frontiers published new progress about Alkynylation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Recommanded Product: Ethyl 3-oxo-3-phenylpropanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Singer, Herbert; Shive, Wm. published the artcile< Synthesis of 7-nitroindole>, Electric Literature of 112-63-0, the main research area is .

Heating 2 g. Et pyruvate o-nitrophenylhydrazone in 10 g. polyphosphoric acid on a steam bath with stirring until homogeneous, then heating the mixture in an oil bath 5 min. at 195°, cooling it to 50°, adding 25 cc. H2O, heating it again on a steam bath, extracting the precipitate again with hot water, extracting the aqueous solution with Et2O, and recrystallizing the residue of the washed (NaHCO3) Et2O solution from aqueous EtOH yield 13.4% Et 7-nitro-2-indolecarboxylate (I), m. 92-3°. Warming 100 mg. I a few min. with 10 cc. 10% KOH, adding an equal amount of H2O, and acidifying the filtered solution give 56% free acid (II), pale yellow needles, m. 271-2°. Heating 100 mg. II in 3 cc. quinoline containing a trace of Cu chromite 2 hrs. at 205° with stirring, pouring the mixture into 4 cc. concentrated HCl, extracting it with Et2O, and evaporating the Et2O give 49.5% 7-nitroindole, deep yellow needles, m. 95-6°, λ 232, 364, plateau at 248-50 mμ (EtOH); it gives a deep red color with Kovac reagent.

Journal of Organic Chemistry published new progress about UV and visible spectra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, X. Chelsea; Zhang, Yiman; Merrill, Laura C.; Soulen, Charles; Lehmann, Michelle L.; Schaefer, Jennifer L.; Du, Zhijia; Saito, Tomonori; Dudney, Nancy J. published the artcile< Gel composite electrolyte - an effective way to utilize ceramic fillers in lithium batteries>, Quality Control of 112-63-0, the main research area is gel composite electrolyte ceramic filler lithium battery.

Achieving synergy between ion-conducting polymers and ceramics in a composite electrolyte has been proven to be difficult as the complicated ceramic/polymer interface presents challenges to understand and control. In this work, we report a strategy to utilize discrete ceramic fillers to form a gel composite electrolyte with enhanced transport properties for lithium metal batteries. The matrix of the composite membrane is crosslinked poly(ethylene oxide) with bis(trifluoromethane)sulfonimide lithium salt (LiTFSI). The membrane is plasticized with tetraethylene glycol di-Me ether (TEGDME). The incorporation of doped-lithium aluminum titanium phosphate particles (LICGC) into the membrane greatly improves the membrane’s cycling characteristics against the lithium electrode, exhibiting lower interfacial impedance, lower overpotential and higher rate capability. The underpinnings of the superior performance of the gel composite electrolyte are discussed in depth. LICGC can immobilize the TFSI- anions in the polymer matrix and simultaneously promote Li+ transport by increasing the plasticizer to Li+ ratio. Further, the transport enhancement is achieved without sacrificing mech. properties. The composite membrane shows significantly improved handleability and processability. This work sheds light on the design strategy for a safe electrolyte towards stable Li metal batteries.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Activation energy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Binyu; Wen, Xiaolu; Chen, Hongbing; Hu, Lin published the artcile< N-Nosyl-O-bromoethyl hydroxylamine acts as a multifunctional formaldehyde, formaldimine, and 1,2-oxazetidine surrogate for C-C and C-O bond-forming reactions>, Application of C11H12O3, the main research area is aminomethyl ketone preparation; nosyl bromoethyl hydroxylamine benzoyl acetate bond formation; hydroxymethyl ketone preparation; hydroxy ketone nosyl bromoethyl hydroxylamine bond formation; carboxylate indanone hydroxymethyl preparation enantioselective chemoselective; alkoxyl indanone carboxylate preparation enantioselective chemoselective; indanone carboxylate bond formation Mannich chiral catalyst.

N-Nosyl-O-bromoethyl hydroxylamine, a bench stable solid, could function as a novel formaldehyde, formaldimine and 1,2-oxazetidine surrogate under DBU basic conditions were described. By merely using this simple reagent, a broad range of synthetically useful β-aminomethyl ketones I [R1 = Me, Ph, 2-furyl, etc.; R2 = Me, Et, allyl, Bn; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.; R3 = Ac, CO2Me, CO2Et, SO2Ph] and α-hydroxymethyl ketones II [R4 = Me, Et, allyl, Bn; Q = (CH2)n, n = 1,2], as well as chiral α-alkoxyl indanone carboxylates III [R5 = H, 4-MeO, 5-F, etc.; X = OCH2CH2] and α-aminomethyl indanone carboxylates III [X = CH2] could be divergently obtained via chemo- and stereoselective aldol, Mannich or umpolung C-O bond-forming reactions. The challenging catalytic asym. Mannich reaction of formaldimine equivalent was also realized with moderate enantioselectivities.

Organic Chemistry Frontiers published new progress about Bond formation. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Application of C11H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cho, Hyungjun; Liu, Peng; Boyle, Amanda J.; Reilly, Raymond M.; Winnik, Mitchell A. published the artcile< Synthesis of a metal-chelating polymer with NOTA pendants as a carrier for 64Cu, intended for radioimmunotherapy>, Category: esters-buliding-blocks, the main research area is metal chelating polymer NOTA pendant copper64 carrier radioimmunotherapy.

As a positron emitter, 64Cu is useful for positron emission tomog. It can also generate Auger electrons that are useful for therapy. Many radioimmunoconjugates labeled with 64Cu involve covalent attachment of bifunctional chelators directly to the antibody (Ab) of interest. To increase its therapeutic potential, a metal-chelating polymer (MCP) with multiple chelators can be conjugated the Ab. In this way, one can incorporate multiple 64Cu ions per Ab. Here we describe the synthesis of a MCP designed for attachment to trastuzumab (tmab), an antibody (Ab) used to treat breast cancer patients with tumors that overexpress human epidermal growth factor receptor 2. We chose 1,4,7-triazacyclononane-N,N′,N′′-triacetic acid (NOTA) chelator to complex with 64Cu, and in our design, the polymer would carry multiple copies of the NOTA chelator as pendant groups. The Cu2+/NOTA complex has a net neg. charge. We began by using RAFT polymerization to synthesize an end-functional poly(2-aminoethyl acrylamide) polymer, in which we could use the amino groups to attach the chelator and other substituents. In a previous study (Biomacromols. 13 (2012) 2831-2842), we found that MCP radioimmunoconjugates with a neg. charge in the repeat unit led to high liver up-take in a mouse model. Thus, we chose to introduce ca. 50% methoxy-dodecaethylene glycol (mPEG12) pendant groups to confer “”stealth””. As a control, we also synthesized a similar polymer with ca. 50% methoxyethyl pendants (EO1). NOTA chelators were attached to remaining pendant groups. We then end-capped the MCPs with succinic acid, radiolabeled the MCPs with 64Cu and injected the radiolabeled MCPs into healthy Balb/c mice via the tail vein. We observed that a large amount of the MCPs were retained in the kidneys. We discuss what properties of the MCPs may have contributed to its accumulation in the kidneys.

European Polymer Journal published new progress about Antibodies and Immunoglobulins Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Garuti, Laura; Roberti, Marinella; De Clercq, Erik published the artcile< Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles>, Reference of 112-63-0, the main research area is benzimidazolyl sulfone antiviral antiproliferative preparation.

Some benzimidazolyl sulfones were synthesized and evaluated for their antiviral and antiproliferative properties. I (R = CHMe2) displayed significant and selective activity against human cytomegalovirus (CMV), I (R = 3-NO2-C6H4) showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives Some structure-activity relationships are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Huijun; Gao, Hua; Liu, Kun; Liu, Zhantao; Wang, Jian; Li, Wenjun published the artcile< Cycloadduct formation of α,β-unsaturated esters with azides catalyzed by NHC systems>, Electric Literature of 112-63-0, the main research area is cycloaddition unsaturated ester azide preparation triazole dihydropyrazole organocatalyst NHC.

1,2,3-Triazoles and aminomethylpyrazoles were prepared by 1,3-cycloaddition of azides with α,β-unsaturated esters organocatalyzed by N-heterocyclic carbenes, formed in situ from imidazolium and 1,2,4-triazolium salts. NHC-catalyzed cycloadduct formation of α,β-unsaturated esters with azides has been developed. This strategy could generate 1,2,3-triazoles and dihydropyrazoles with high yields and regioselectivities in the presence of an N-heterocyclic carbene catalyst. The broad substrate scope and mechanistic survey of this process are also presented.

Organic & Biomolecular Chemistry published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xingru; Guo, Rui; Zhao, Yaxuan; Liu, Danping; Chen, Jing; Miao, Ningning; Gao, Shujuan; Guo, Jixun; Zhang, Tao; Shi, Lianxuan published the artcile< Wild soybean resists the stress of low phosphorus by increasing nutrient reuse between the young and old leaves>, Electric Literature of 112-63-0, the main research area is Glycine leaf age nutrient phosphorus deficiency metabolomics.

Screening and identification of plant resources with high quality and multi resistance is important for crop breeding. In this study, ion content was determined by ion chromatog. and at. absorption spectrophotometer, and gas chromatog.-mass spectrometry (GC-MS)-based metabolomic anal. was carried out. Then metabolic pathways were constructed using the Kyoto Encyclopedia of Genes and Genomes and the MetaboAnalyst website to compare the changes and differences of young and old leaves of two wild soybean lines with different stress tolerance under low-phosphorus (LP) stress. The aim was to reveal the mechanism of wild soybean resistance to LP stress from insights concerning nutrient accumulation and mobilization. The results showed that in LP-tolerant wild soybean, Ca2+ accumulated and TCA, amino acid and organic acid metabolisms were enhanced in young and old leaves; disaccharide and trisaccharide metabolism was enhanced and phosphohexose metabolism was inhibited in old leaves; Mg2+, disaccharide and trisaccharide contents increased in young leaves, while inorganic P was relatively stable. Our experiment highlighted that LP-tolerant wild soybean adapted to LP stress by enhancing energy and material metabolisms and maintaining the growth and development of young leaves at the expense of old leaves, which is of great significance for the development and utilization of germplasm resources and the breeding of LP-tolerant soybean.

Plant Growth Regulation published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Merker, Philip C.; Vona, Joseph A. published the artcile< Use of pyridinium bromide perbromide for brominations>, Application of C19H34O2, the main research area is .

Directions are given for student preparation of butyl bromide, p-bromoacetanilide, bromobenzene, and the bromination of anethole.

Journal of Chemical Education published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics