Month: October 2022

Walker, Jeffery W.; Martin, Hunter; Schmitt, Frederick R.; Barsotti, Robert J. published the artcile< Rapid release of an α-adrenergic receptor ligand from photolabile analogs>, Formula: C9H9NO4, the main research area is alpha adrenergic receptor agonist photorelease; phenylephrine analog photorelease adrenergic receptor.

A series of 2-nitrobenzyl derivatives of the α1-selective adrenergic agonist, L-phenylephrine [(R)-N-[2-(3-hydroxyphenyl)-2-hydroxyethyl]-N-methylammonium chloride], were synthesized and characterized for the purpose of developing biol. inert compounds that can be rapidly converted to L-phenylephrine by near-UV irradiation The compounds, derivatized on the phenolic oxygen, were O-(1-(2-nitrophenyl)ethyl)phenylephrine (I), O-(2-nitrobenzyl)phenylephrine (II), O-(4,5-dimethoxy-2-nitrobenzyl)phenylephrine (III), and O-(α-carboxyl-2-nitrobenzyl)phenylephrine (IV). All 4 compounds photolyzed to free phenylephrine following a brief exposure to 300-350-nm light or 347-nm laser light with steady-state quantum yields ranging from 0.05 to 0.28. The rates of phenylephrine formation on photolysis were estimated from the decay rates of aci-nitro intermediates detected by absorbance between 380 and 500 nm. IV displayed the highest quantum yield (0.28) and most rapid photolysis rate (1980 s-1) measured under near physiol. conditions, pH 8.0, 22°. Biol. properties of the compounds were examined in smooth muscle from rat caudal artery. Laser pulse photolysis of IV at 347 nm initiated a maximal contraction in Krebs buffer, pH 7.1, 25°, that mimicked the response to 50 μM phenylephrine but was faster in onset. Photoinitiated contractions were characterized by a delay of 0.93 s followed by a rising phase with a 10-90% rise time of 3.56 s. Responses were fully blocked by the α1-selective antagonist prazosin. Similar results were obtained using I-III, but a slowly developing sustained phase of smooth muscle contraction was altered in the presence of I-III. IV represents a useful new biol. inactive caged phenylephrine that should facilitate temporally and spatially resolved studies of α1-adrenergic receptor mechanisms in cells and tissues.

Biochemistry published new progress about Caudal artery. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Bum Hoon; Jaung, Jae Yun; Jang, Se Chan; Yi, Sung Chul published the artcile< Synthesis and optical properties of push-pull type tetrapyrazinoporphyrazines>, Category: esters-buliding-blocks, the main research area is pyrazinoporphyrazine copper complex dye preparation fluorescence absorption spectra.

The optical properties of push-pull type tetrapyrazinoporphyrazine copper complexes based on 2,3-dicyanopyrazines were demonstrated. They have an alkoxyphenyl substituent as an electron donor group at the 5-position, and nitrophenyl or octylsulfonylphenyl substituents as an electron acceptor group at the 6-position of the 2,3-dicyanopyrazines. The absorption and fluorescence maxima of nitro-substituted compounds were observed at 427-444 and 453-494 nm, resp. In the case of the sulfonyl-substituted compounds, the hypsochromic shift of absorption and fluorescence maxima were 59-104 and 13-79 nm, resp.

Dyes and Pigments published new progress about Dyes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Martin-Nieves, Virginia; Sanghvi, Yogesh S.; Fernandez, Susana; Ferrero, Miguel published the artcile< Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is 2′,3′-didehydro-2′,3′-dideoxynucleosides; 2′,3′-dideoxynucleosides; didanosine (ddI); stavudine (d4T); synthesis; zalcitabine (ddC).

An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established. The process involves radical deoxygenation of xanthate using environmentally friendly and low-cost reagents. Bromoethane or 3-bromopropanenitrile was the alkylating agent of choice to prepare the ribonucleoside 2′,3′-bisxanthates. In the subsequent radical deoxygenation reaction, tris(trimethylsilyl)silane and 1,1′-azobis(cyclohexanecarbonitrile) were used to replace hazardous Bu3SnH and AIBN, resp. In addition, TBAF was substituted for camphorsulfonic acid in the deprotection step of the 5′-O-silyl ether group, and an enzyme (adenosine deaminase) was used to transform 2′,3′-dideoxyadenosine into 2′,3′-dideoxyinosine (ddI) in excellent yield.

Molecules published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qin, Qiyu; Yu, Naiji; Gu, Yuxiang; Ke, Weishaer; Zhang, Qi; Liu, Xin; Wang, Kaijun; Chen, Min published the artcile< Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury>, Product Details of C15H22N2O2, the main research area is necrostatin1 ferrostain1 neuroprotective agent retinal ischemia reperfusion injury.

Progressive retinal ganglion cells (RGCs) death that triggered by retinal ischemia reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of post-IR neuronal death and related mechanisms is limited. In this study, we first demonstrated that apart from necroptosis, which occurs before apoptosis, ferroptosis, which is characterized by iron deposition and lipid peroxidation, is involved in the whole course of retinal IR in mice. Correspondingly, all three types of RGCs death were found in retina samples from human glaucoma donors. Further, inhibitors of apoptosis, necroptosis, and ferroptosis (z-VAD-FMK, Necrostatin-1, and Ferrostatin-1, resp.) all exhibited marked RGC protection against IR both in mice and primary cultured RGCs, with Ferrostatin-1 conferring the best therapeutic effect, suggesting ferroptosis plays a more prominent role in the process of RGC death. We also found that activated microglia, Muller cells, immune responses, and intracellular reactive oxygen species accumulation following IR were significantly mitigated after each inhibitor treatment, albeit to varying degrees. Moreover, Ferrostatin-1 in combination with z-VAD-FMK and Necrostatin-1 prevented IR-induced RGC death better than any inhibitor alone. These findings stand to advance our knowledge of the post-IR RGC death cascade and guide future therapy for RGC protection.

Cell Death & Disease published new progress about Apoptosis. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Zhonghe; Wang, Mu; Li, Zhi; Choi, Bonnie; Mulder, Roger J.; Feng, Anchao; Moad, Graeme; Thang, San H. published the artcile< Versatile Approach for Preparing PVC-Based Mikto-Arm Star Additives Based on RAFT Polymerization>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is versatile preparing PVC mikto arm star RAFT polymerization.

A versatile approach to the synthesis of migration-resistant poly(vinyl chloride) (PVC) additives is described and a preliminary assessment of their properties is presented. The process involves the synthesis of AB2 3-mikto-arm stars, star-[PVC-block-(polyB);(polyB)2] or star-[PVC;(polyB)2], that contain a reversible addition-fragmentation chain transfer (RAFT)-synthesized PVC segment, to provide compatibility with PVC and good migration resistance, and multiple RAFT-synthesized segments (polyB), where polyB is based on more activated monomer (a styrene or a methacrylate) that contains the functionality required to impart the desired additive properties. The approach to PVC-based stars comprises three steps: (a) synthesis of a hydroxy-functional PVC [X-PVC(OH)n] by RAFT polymerization mediated by a hydroxy-functional xanthate [X-(OH)n], (b) conversion of the X-PVC(OH)n to the corresponding trithiocarbonate, X-PVC-(CDTPA)n, by the Steglich esterification with 4-cyano-4-[(dodecylsulfanylthiocarbonyl)sulfanyl]pentanoic acid (CDTPA), and (c) formation of star polymer additives by RAFT polymerization mediated by X-PVC-(CDTPA)n. The stars prepared include a plasticizer (B = Bu acrylate), a reactive dispersant for use in forming silica nanocomposites (B = 3-methacryloxypropyltrimethoxysilane), UV stabilizers (B = 2-[3-(2H-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl methacrylate or 2-hydroxy-4-acryloxybenzophenone), and flame retardants (B = 4-vinylbenzyl phosphonate or diethyl(methacryloyloxymethyl)phosphonate). Although much optimization remains to be done, our preliminary study shows that the synthesized mikto-arm star additives can be effective in imparting the anticipated properties to PVC.

Macromolecules (Washington, DC, United States) published new progress about Dispersing agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Viswanatha, T.; Bayer, E.; Wilchek, Meir published the artcile< Reversibility of the affinity-labeled biotin transport system in yeast cells>, Formula: C19H34O2, the main research area is biotin transport Saccharomyces.

Transport of biotin by Saccharomyces cerevisiae is inhibited by biotynyl p-nitrophenyl ester. Conversion of the inhibited cells to spheroplasts or simple treatment with thiols results in a total restoration of vitamin transport. Biotinyl p-nitrophenyl ester-induced inhibition is not due to an intracellular accumulation of the vitamin and consequent regulation, but appears to be due to specific labeling of the transport system.

Biochimica et Biophysica Acta, Biomembranes published new progress about Biological transport. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fomitskaya, Polina A.; Argunov, Dmitry A.; Tsvetkov, Yury E.; Lalov, Andrey V.; Ustyuzhanina, Nadezhda E.; Nifantiev, Nikolay E. published the artcile< Further Investigation of the 2-Azido-phenylselenylation of Glycals>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is oligosaccharide aminodeoxy sugar azidodeoxy bacterial synthon stereoselective azidophenylselenylation glycal; crystal structure azidophenylselenylation glycal mannopyranoside azidodeoxyseleno glycoside preparation acetoxyphenylselenylation.

Derivatives of 2-azido-2-deoxy sugars are widely applied as precursor of 2-amino-2-deoxy sugars in the synthesis of various oligosaccharides of bacterial, fungal and mammalian origin. Heterogeneous or homogeneous azidophenylselenylation (APS) of glycals, i. e., reaction of glycals with Ph2Se2, PhI(OAc)2 and NaN3 or TMSN3 as azide radical donors, is a straightforward way to Ph 2-azido-2-deoxy-1-selenoglycosides that can be directly used as glycosyl donors. However, heterogeneous APS is characterized by insufficient reproducibility and scalability. We have studied the effect of reaction conditions on the product distribution in heterogeneous APS of 3,4,6-tri-O-acetyl-D-galactal and found the conditions that enabled reliable preparation of crystalline Ph 2-azido-2-deoxy-1-seleno-α-D-galactopyranoside triacetate in yield of 58% on the 3.7 mmol scale. APS of 3,4,6-tri-O-acetyl-D-glucal under those conditions produced a ∼1 : 1 mixture of Ph 2-azido-2-deoxy-1-seleno-α-D-gluco- and mannopyranosides in total yield of 78%. Acetoxyphenylselenylation of differently protected galactals and 3,4,6-tri-O-acetyl-D-glucal under the action of Ph2Se2 and PhI(OAc)2 has been shown to be a convenient method for the synthesis of 1-O-acetyl-2-seleno-2-deoxy derivatives, valuable intermediates in chem. of 2-deoxysugars. 2-Seleno-2-deoxy sugars were characterized in detail by NMR data including 77Se chem. shifts and nJSe-H coupling constant values.

European Journal of Organic Chemistry published new progress about Crystal structure. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bubenchikova, V. M.; Popova, T. P.; Litvinenko, V. I. published the artcile< The flavonoids of medicinal dandelions>, SDS of cas: 112-63-0, the main research area is dandelion flavonoid luteolin.

Medicinal dandelion contained 1.35% flavonoids, the major compound being luteolin comprising 0.8% of the crude drug.

Farmatsevtichnii Zhurnal (Kiev) published new progress about Flavonoids Role: BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seidel, F.; Thier, W.; Uber, A.; Dittmer, J. published the artcile< The formation of ""triacetylacetic ester."" II>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is .

It had been reported that in the preparation of Ac2CHCO2Et according to Claissen there is also formed Ac3CCO2Et (I), since the reaction product gave with N2H4 a product (II) assumed to be Et 3,5-dimethylpyrazole-4-acetyl-4-carboxylate (III). v. Auwers (C. A. 27, 62) doubts the existence of I and the correctness of the structure III for II. It has now been found that II changes above its m. p. into β-(5-hydroxy-3-methyl-4-pyrazolyl)crotonolactone (IV), and hence II is not a condensation product of I with N2H4 but Et β-(5-hydroxy-3-methyl-4-pyrazolyl)crotonate (V). The N2H4 first deacetylates the Ac2CHCO2Et in the reaction mixture, forming AcCH2CO2Et and AcNHNH2 (the greater part of the N2H4 thus escaping further reaction), and the unchanged N2H4 condenses with a part of the AcCH2CO2Et to 3-methyl-5-pyrazolone which combines with the rest of the AcCH2CO2Et to form V with loss of water. All attempts to prepare the true III (which is isomeric with IV) were unsuccessful, but they yielded hitherto unknown intermediate products which not only contributed to the knowledge of the reactivity of the pyrazoles and pyrazolones but also helped to establish the structure of V with certainty. Et 3,5-dimethylpyrazolone-4-carboxylate (VI), from Ac2CHCO2Et (reacting in the mono-enolic form, of which the equilibrium mixture contains 91.8%) and N2H4, gives with AcCl the 1-Ac derivative (VII) which, after saponification, is decarboxylated to 1-acetyl-3,5-dimethylpyrazole (VIII). The structure of VIII is established: (1) by condensing Ac2CH2 (76% enol) with N2H4 to 3,5-dimethylpyrazole (IX) and acetylating IX to VIII with AcCl in pyridine; (2) by synthesis of VIII from Ac2CH2 and NH2NHAc. Direct replacement of the 4-H atom on the pyrazole nucleus by acyl is not possible; to obtain 3,5-dimethyl-4-acetylpyrazole (X), CHAc3 (88.3% enol at equilibrium) must be condensed with N2H4. It reacts with AcCl to form the 1,4-di-Ac derivative (XI). It was hoped that IV (or the free acid) might be obtained by saponifying isodehydracetic ester to HO2CCH:CMeC(CO2Et):C(OH)Me and condensing the latter with N2H4, but the product was always only 3-methyl-5-pyrazolone, the isodehydracetic ester evidently breaking down into AcCH2CO2Et under even the mildest conditions. Definite proof that 3-methyl-5-pyrazolone reacts at the 4-position with AcCH2CO2Et to form V was obtained indirectly. Reaction through the NH group is excluded, for 3,4,4-trimethyl-5-pyrazolone does not react with AcCH2CO2Et but 1-phenyl-3-methylpyrazolone does, yielding Et (β-5-hydroxy-1-phenyl-3-methyl-4-pyrazolyl)crotonate (XII), which splits off EtOH at 165° to form the lactone (XIII). Further evidence that the NH group is not involved in the condensation is afforded by the fact that IV forms a Bz derivative V, obtained in 24 g. yield from a charge of 638 g. AcCH2CO2Et, 88.6 g. Na and 600 g. AcCl, m. 188°, is also obtained readily by Wolff’s method (Ber. 38, 3038(1905)); it is stable toward boiling MeOH and alc. NH3 but with PhNHNH2 and concentrated KOH gives 3-methyl-5-pyrazolone. IV, m. 246°. Free acid, from IV and 10% NaOH at 15-20°, m. 154° (decomposition), regenerates IV on heating in vacuo at 15-20° or in hot alc. VII (6.2 g. from 7.0 g. VI), m. 69°; free acid, similarly obtained (6.0 g.) from the free acid (5.0 g.) of VI, m. 164°. VIII, b12 70°, b23 84°. 1-Bz analog, b12 158°. X, needles with 1 H2O, m. 121° (decomposition) and (anhydrous) 128°. XI, m. 50°. XII, m. 88°. XIII, light yellow, m. 132°. 1-Bz derivative of VI, m. 181°.

Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pandiangan, K. D.; Simanjuntak, W.; Alista, D. I.; Ilim, I. published the artcile< The effect of NiO loads on catalytic activity of NiO/ZSM-5 for transesterification of rubber seed oil>, COA of Formula: C19H34O2, the main research area is transesterification rubber seed oil nickel oxide ZSM5.

In this investigation, a series of NiO/ZSM-5 with different NiO loads were produced and applied to catalyze transesterification of rubber seed oil (RSO) with methanol. ZSM-5 was prepared using hydrothermal technique from rice husk silica (RHS) and Al(OH)3 without using a template and then impregnated with Ni(NO3)2 solution of different concentrations followed by 6 h calcination at 600°C. Characterizations were performed with Fourier transform IR (FTIR) spectroscopy, x-ray diffraction (XRD), scanning electron microscope (SEM), and x-ray fluorescence (XRF). The establishment of ZSM-5 was confirmed by XRD and SEM, and NiO/ZSM-5 by XRD, SEM, and XRF. Catalytic activity tests demonstrate a significant enhancement of performance of NiO/ZSM-5 compared to that of ZSM-5 without NiO. Practically complete conversion of RSO into Me esters was achieved with the use of NiO/ZSM-5 catalysts prepared using 5, 10, and 15% nickel solution; however, decreases with the use of 20% nickel solution In this respect, it can be concluded that a 5% nickel solution is sufficient to produce NiO/ZSM-5 enabling complete conversion of RSO into biodiesel, suggesting that NiO/ZSM-5 is a prospective heterogeneous catalyst for biodiesel production

Rasayan Journal of Chemistry published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics