Month: October 2022

Liu, Xizheng; Lei, Xiaofeng; Wang, Yong-Gang; Ding, Yi published the artcile< Prevention of Na Corrosion and Dendrite Growth for Long-Life Flexible Na-Air Batteries>, HPLC of Formula: 112-63-0, the main research area is flexible NAB dendrite growth corrosion gel electrolyte modified anode.

Rechargeable Na-air batteries (NABs) based on abundant Na resources are generating great interest due to their high energy d. and low cost. However, Na anode corrosion in ambient air and the growth of abnormal dendrites lead to insufficient cycle performance and safety hazards. Effectively protecting the Na anode from corrosion and inducing the uniform Na plating and stripping are therefore of vital importance for practical application. We herein report a NAB with in situ formed gel electrolyte and Na anode with trace residual Li. The gel electrolyte is obtained within cells through crosslinking Li ethylenediamine at the anode surface with tetraethylene glycol di-Me ether (G4) from the liquid electrolyte. The gel can effectively prevent H2O and O2 crossover, thus delaying Na anode corrosion and electrolyte decomposition Na dendrite growth was suppressed by the electrostatic shield effect of Li+ from the modified Li layer. Benefiting from these improvements, the NAB achieves a robust cycle performance over 2000 h in opened ambient air, which is superior to previous results. Gelation of the electrolyte prevents liquid leakage during battery bending, facilitating greater cell flexibility, which could lead to the development of NABs suitable for wearable electronic devices in ambient air. The Na-air batteries have been developed with in situ formed gel electrolyte on a Li modified Na anode. They display ultrastable cycle performance up to 2000 h in ambient air.

ACS Central Science published new progress about Battery anodes. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Riand, J.; Chenon, M. T.; Lumbroso-Bader, N. published the artcile< Carbon-13 NMR study of substituent effects in the pyrimidine nucleus>, Synthetic Route of 112-63-0, the main research area is pyrimidine substituent effect NMR; carbon NMR pyrimidine.

Twenty-one pyrimidines were studied by 13C NMR, and the effect of Me and NH2 substituents on the chem. shifts determined Pair parameters derived from observed and calculated chem. shifts of disubstituted pyrimidines were used to calculate chem. shifts of tri- and tetrasubstituted pyrimidines.

Tetrahedron Letters published new progress about NMR (nuclear magnetic resonance). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Feng; Yang, Chao; Li, Feng-Ping; Yu, Dong-Hu; Pan, Zhi-Yong; Wang, Ze-Fen; Li, Zhi-Qiang published the artcile< Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression>, Electric Literature of 112-63-0, the main research area is palmitoyl transferase tumor infiltrating immune cell glioma progression; MT: Bioinformatics; ZDHHCs; gliomas; immune-cell infiltration; post-translational modification; signaling pathway.

High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune microenvironment. In the present study, a large cohort of patients with gliomas from The Cancer Genome Atlas (TCGA) and Rembrandt databases was included to perform omics anal. of ZDHHCs in gliomas. CCK-8, flow cytometry, quant. real-time PCR, western blotting, and transwell assays were performed to determine the effects of ZDHHC inhibition on glioma cells and microglia. We found that five (ZDHHC11, ZDHHC12, ZDHHC15, ZDHHC22, and ZDHHC23) out of 23 ZDHHCs were aberrantly expressed in gliomas and might play their roles through the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Further results indicated that inhibition of ZDHHCs with 2-bromopalmitate (2-BP) suppressed glioma-cell viability and autophagy, as well as promoted apoptosis. Targeting ZDHHCs also promoted the sensitivity of glioma cells to temozolomide (TMZ) chemotherapy. In addition, the inhibition of ZDHHCs weakened the migratory ability of microglia induced by glioma cells in vitro and in vivo. Taken together, our findings suggest that the inhibition of ZDHHCs suppresses glioma-cell viability and microglial infiltration. Targeting ZDHHCs may be promising for glioma treatments.

Molecular Therapy–Nucleic Acids published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (ZDHHC11). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Madhusudan, Srinivasan; Smart, Fiona; Shrimpton, Paul; Parsons, Jason L.; Gardiner, Laurence; Houlbrook, Sue; Talbot, Denis C.; Hammonds, Timothy; Freemont, Paul A.; Sternberg, Michael J. E.; Dianov, Grigory L.; Hickson, Ian D. published the artcile< Isolation of a small molecule inhibitor of DNA base excision repair>, Application of C19H34O2, the main research area is inhibitor DNA base excision repair inhibitor CRT0044876 human antitumor; apurinic apyrimidinic endonuclease DNA damage repair inhibitor.

The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation A key step in BER is the processing of an apurinic/apyrimidinic (AP) site intermediate by an AP endonuclease. The major AP endonuclease in human cells (APE1, also termed HAP1 and Ref-1) accounts for >95% of the total AP endonuclease activity, and is essential for the protection of cells against the toxic effects of several classes of DNA damaging agents. Moreover, APE1 overexpression has been linked to radio- and chemo-resistance in human tumors. Using a newly developed high-throughput screen, several chem. inhibitors of APE1 have been isolated. Amongst these, CRT0044876 was identified as a potent and selective APE1 inhibitor. CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1 at low micromolar concentrations, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds This enhancement of cytotoxicity is associated with an accumulation of unrepaired AP sites. In silico modeling studies suggest that CRT0044876 binds to the active site of APE1. These studies provide both a novel reagent for probing APE1 function in human cells, and a rational basis for the development of APE1-targeting drugs for antitumor therapy.

Nucleic Acids Research published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsvetkov, Peter; Coy, Shannon; Petrova, Boryana; Dreishpoon, Margaret; Verma, Ana; Abdusamad, Mai; Rossen, Jordan; Joesch-Cohen, Lena; Humeidi, Ranad; Spangler, Ryan D.; Eaton, John K.; Frenkel, Evgeni; Kocak, Mustafa; Corsello, Steven M.; Lutsenko, Svetlana; Kanarek, Naama; Santagata, Sandro; Golub, Todd R. published the artcile< Copper induces cell death by targeting lipoylated TCA cycle proteins>, COA of Formula: C15H22N2O2, the main research area is copper cell death TCA cycle mitochondrial respiration homeostasis PDHA1.

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown. Here, we show in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration. We show that copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death. These findings may explain the need for ancient copper homeostatic mechanisms.

Science (Washington, DC, United States) published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (DBT). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, COA of Formula: C15H22N2O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Ce; Zhang, Pingping; Chen, Zhenghong; Liu, Yang; Zhao, Li; Wang, Nan; Xu, Baocai published the artcile< Effects of fatty acyl chains on the interfacial rheological behaviors of amino acid surfactants>, HPLC of Formula: 112-63-0, the main research area is fatty acyl chain amino acid surfactant interfacial rheol behavior.

Amino acid surfactants derived from vegetable oils have attracted significant interest in the scientific community due to their excellent biocompatibility and low environmental impact. Because of the wide variety of vegetable oils, derived N-acyl amino acid surfactants may feature various fatty acyl groups and therefore offer diverse properties. According to the composition of commonly used vegetable oils, three main characteristics of fatty acyl structures, namely fatty acyl chain length, the number of C=C bonds, and hydroxyl substituent, were summarized in this paper and a series of N-fatty acyl glycinate surfactants were synthesized. The specific effects of these three structural factors on the surface tension and interfacial rheol. properties were systematically studied. In doing so, we found that an increase of fatty acyl chain length enhanced the interfacial activity and intermol. interactions of N-fatty acyl glycinate surfactants. Thus, glycinate surfactants with longer fatty acyls could generate more compact adsorption films with a higher dilational modulus. The cis C=C bonds in oleoyl and linoleoyl chains were found to bend the long hydrophobic tails, which might affect the compact arrangement of surfactant mols. and increased the viscoelasticity of interfacial films. In addition, the hydroxyl group on ricinoleoyl was found to inhibit the close packing of the hydrophobic tails and reduced intermol. interactions. As a result, more viscoelastic films were formed by sodium N-ricinoleoylglycinate. The obtained results gained insights into the relationships between fatty acyl structural characteristics and the interfacial arrangements of N-acyl amino acid surfactants, which present a theor. foundation for surfactant design and further application.

Journal of Molecular Liquids published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent) (N-acyl derivatives). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Davis, Dexter C.; Mohammad, Haroon; Kyei-Baffour, Kwaku; Younis, Waleed; Creemer, Cassidy Noel; Seleem, Mohamed N.; Dai, Mingji published the artcile< Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus>, Synthetic Route of 112-63-0, the main research area is aryl isonitrile methicillin vancomycin resistant Staphylococcus; Antibiotic; Drug resistance; Isonitrile; MRSA; VRSA.

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) have emerged as a global health concern. A new class of compounds featuring an aryl isonitrile moiety has been discovered that exhibits potent inhibitory activity against several clin.-relevant MRSA and VRSA isolates. Structure-activity relationship studies have been conducted to identify the aryl isonitrile group as the key functional group responsible for the observed antibacterial activity. The most potent antibacterial aryl isonitrile analogs (MIC 2 μM) did not show any toxicity against mammalian cells up to a concentration of 64 μM.

European Journal of Medicinal Chemistry published new progress about Antibiotics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wegenhart, Benjamin L.; Yang, Linan; Kwan, Soon Cheong; Harris, Remi; Kenttaemaa, Hilkka I.; Abu-Omar, Mahdi M. published the artcile< From Furfural to Fuel: Synthesis of Furoins by Organocatalysis and their Hydrodeoxygenation by Cascade Catalysis>, Application of C19H34O2, the main research area is furfural fuel furoin derivative organocatalysis hydrodeoxygenation cascade catalysis; biomass; carbenes; hydrocarbons; organocatalysis; palladium.

The synthesis of furoins from biomass-derived furfural and 2-methylfurfural is demonstrated in high yields in green and renewable solvents using N-heterocyclic carbene organocatalysts. The resulting furoin mols. are used as precursors for fuels using cascade catalysis, 1st by using Pd/C with acidic co-catalysts under very mild conditions to yield oxygenated C12 mols. Two main products were formed, which the authors identified as 1,2-bis(5-methylTHF-2-yl)ethane and 1-(5-methylTHF-2-yl)heptanol. The use of a Pd/Zeolite-β catalyst under more extreme conditions resulted in the complete hydrodeoxygenation of 5,5′-dimethylfuroin to dodecanes in high yields (76 %) and exceptional selectivity (94 %) for n-dodecane.

ChemSusChem published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lei; Zhou, Xia; Lu, Hui; Mu, Xianfu; Jin, Linhong published the artcile< Synthesis and antibacterial evaluation of novel 1,3,4-oxadiazole derivatives containing sulfonate/carboxylate moiety>, Category: esters-buliding-blocks, the main research area is sulfonate carboxylate oxadiazole preparation agrochem antibacterial activity; 1,3,4-oxadiazole derivatives; antibacterial activity; scanning electron microscopy; xanthomonas axonopodis pv. Citri; xanthomonas oryzae pv. oryzae.

Novel sulfonate/carboxylate functionalized 1,3,4-oxadiazole derivatives I (R1 = Me, Et, 2-fluoroethyl; R2 = Ph, 2-fluorophenyl, 4-chlorophenyl, etc.) and II [R1 = Me; R3 = Ph, 4-bromophenyl, N(CH3)2, etc.] were synthesized and evaluated for their antibacterial activities. Antibacterial activity against two phytopathogens, Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), was assayed in vitro. The preliminary results indicated that ten compounds including I [R1 = Ph, R2 = Me (A); R1 = 4-fluorophenyl, R2 = Me (B); R1 = 4-chlorophenyl, R2 = Me (C); R1 = 4-bromophenyl, R2 = Me (D); R1 = 4-fluorophenyl, R2 = Et; R1 = 4-chlorophenyl, R2 = Et; R1 = 4-bromophenyl, R2 = Et; R1 = 4-fluorophenyl, R2 = 2-fluoroethyl; R1 = 4-chlorophenyl, R2 = 2-fluoroethyl; R1 = 4-bromophenyl, R2 = 2-fluoroethyl] had good antibacterial activity against Xoo, with EC50 values ranging from 50.1-112.5μM, which was better than those of Bismerthiazol (253.5μM) and thiadiazole copper (467.4μM). Meanwhile, compounds(A), (B), (C), (D) demonstrated good inhibitory effect against Xanthomonas axonopodis pv. citri with EC50 values around 95.8-155.2μM which were better than those of bismerthiazol (274.3μM) and thiadiazole copper (406.3μM). In addition, in vivo protection activity of compounds (B), (C) against rice bacterial leaf blight was 68.6% and 62.3%, resp., which were better than bismerthiazol (49.6%) and thiadiazole copper (42.2%). Curative activity of compounds (B), (C) against rice bacterial leaf blight was 62.3% and 56.0%, which were better than bismerthiazol (42.9%) and thiadiazole copper (36.1%). Through SEM (SEM) anal., it was observed that compound (B) caused the cell membrane of Xanthomonas oryzae pv. oryzae ruptured or deformed. The present results indicated novel derivatives of 4-Ph sulfonate Me 1,3,4-oxadiazole I might be potential antibacterial agents.

Molecules published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Basso, Alessandra; Braiuca, Paolo; Ebert, Cynthia; Gardossi, Lucia; Linda, Paolo; Benedetti, Fabio published the artcile< GRID/tetrahedral intermediate computational approach to the study of selectivity of penicillin G acylase in amide bond synthesis>, Safety of Methyl 2-(2-nitrophenyl)acetate, the main research area is penicillin G acylase selectivity active site tetrahedral intermediate.

Mol. modeling was used to investigate the catalytic site of penicillin G acylase (PGA) by building up a simple enzyme-ligand model able to describe and predict the enzyme selectivity. The investigation was based on a double computational approach: first, the GRID computational procedure was applied to gain a qual. description of the chem. features of the PGA active site; second, a classical “”transition state approach”” was used to simulate the tetrahedral intermediates and to evaluate their energies. GRID calculations employed different probes which gave a complete description of the chem. interactions occurring upon binding of different ligands, thus indicating those structures having good affinity with the active site of the enzyme. Tetrahedral intermediates were constructed on the basis of GRID results and provided both geometrical features and energies of enzyme-substrate interaction. Such energies were compared to exptl. kinetic data obtained in the enzymic acylation of L-phenylglycine Me ester using various Me phenylacetate derivatives The good agreement of computational results with exptl. evidence demonstrates the validity of the model as a rapid and flexible tool to describe and predict the enzyme selectivity.

Biochimica et Biophysica Acta, Proteins and Proteomics published new progress about Enzyme functional sites, active. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Safety of Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics