Month: October 2022

Kim, K.-R.; Lee, J.; Ha, D.; Jeon, J.; Park, H.-G.; Kim, J. H. published the artcile< Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography>, Computed Properties of 112-63-0, the main research area is hydroxy acid enantiomer esterification dual capillary column gas chromatog; trifluoroacetylated hydroxy acid enantiomer dual capillary column GC; urine analysis hydroxy acid dual capillary column GC.

An efficient method is described for the simultaneous enantiomeric separation of 18 different racemic 2-hydroxy acids for the determination of their absolute configurations. It involves the conversion of each enantiomer into a diastereomeric O-trifluoroacetylated (S)-(+)-3-methyl-2-Bu ester for the direct separation by achiral dual-capillary column gas chromatog. with subsequent identification and determination of its chirality by retention index (I) library matching. The enantiomers of each acid were well separated with high resolution values (R ≥ 1.4) on DB-5 and DB-17 columns of different polarity. When temperature-programmed I values of 2-hydroxy acid enantiomers as their diastereomeric derivatives were measured on both columns, the I values were characteristic of each enantiomer. Simple I matching with the reference values was thus useful in cross-checking each acid enantiomer for the identification and chiral discrimination. When applied to urine samples, the present method allowed pos. identification of most of the spiked 2-hydroxy acids from normal urine and for endogenous (S)-lactic acid and (S)-2-hydroxybutyric acid from a clin. urine specimen.

Journal of Chromatography A published new progress about Absolute configuration. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Popa, Flavia; Lameiras, Pedro; Henon, Eric; Moldovan, Oana; Martinez, Agathe; Batiu, Carmen; Ramondenc, Yvan; Darabantu, Mircea published the artcile< Amino-s-triazines - Synthesis and stereochemistry of restricted rotational phenomena - First use of a C-2-substituted serinol in tandem with masked 4-piperidone for selective amination of cyanuric chloride>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is aminotriazine preparation restricted rotation; serinol piperidone amination cyanuric chloride.

Starting from 4-piperidone monohydrate hydrochloride (or the hydrochloride of its ethylene ketal) alone, otherwise in tandem with a C-2-substituted 2-aminopropane-1,3-diol (“”serinol””) as amino-nucleophiles in reaction with cyanuric chloride, the synthesis of novel N-substituted amino-s-triazines is reported. The stereochem. of rotational phenomena occurring about the newly created C(s-triazine)-N< (exocyclic) partial double bonds in the title compounds, seen as new dendritic building blocks, is discussed. Canadian Journal of Chemistry published new progress about Amination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Wei; Han, Shuai; Gao, Wei; Feng, Yuan; Li, Kunhang; Wu, Di published the artcile< Long Noncoding RNA KCNQ1OT1 Confers Gliomas Resistance to Temozolomide and Enhances Cell Growth by Retrieving PIM1 From miR-761>, Application of C19H34O2, the main research area is gliomas temozolomide lncRNA KCNQ1OT1 microRNA761; Glioma; Growth; KCNQ1OT1; PIM1; Temozolomide resistance; miR-761.

Abstract:Many studies have found that the dysregulation of long noncoding RNA (lncRNA) contributed to cancer initiation, progression, and recurrence via multiple signaling pathways.However, the underlying mechanisms of lncRNA in temozolomide (TMZ)-resistant gliomas were not well understood, hindering the improvement of TMZ-based therapies. The present study demonstrated that the lncRNA KCNQ1OT1 increased in TMZ-resistant glioma cells compared to the TMZ-sensitive cells.The introduction of KCNQ1OT1 promoted cell viability, clonogenicity, and rhodamine 123 efflux while hampering TMZ-induced apoptosis.Moreover, KCNQ1OT1 directly sponged miR-761, which decreased in TMZ-resistant sublines. The overexpression of miR-761 attenuated cell viability and clonogenicity, while triggering apoptosis and rhodamine 123 accumulation post-TMZ exposure, leading to a response to TMZ. The interaction between miR-761 and 3-untranslated region of PIM1 attenuated PIM1-mediated signaling cascades. Furthermore, the knockdown of KCNQ1OT1 augmented the TMZ-induced tumor regression in TMZ-resistant U251 mouse models. Briefly, the present study evaluated that KCNQ1OT1 conferred TMZ resistance by releasing PIM1 expression from miR-761, resulting in the upregulation of PIM-mediated MDR1, c-Myc, and Survivin. The present findings demonstrated that the interplay of KCNQ1OT1: miR-761: PIM1 regulated chemoresistance in gliomas and provided a promising therapeutic target for TMZ-resistant glioma patients.

Cellular and Molecular Neurobiology published new progress about Animal gene, c-myc Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ouyang, Jia-Sheng; Li, Yan-Fang; Huang, Fei-Dong; Lu, Dong-Dong; Liu, Feng-Shou published the artcile< The Highly Efficient Suzuki-Miyaura Cross-Coupling of (Hetero)aryl Chlorides and (Hetero)arylboronic Acids Catalyzed by ''Bulky-yet-Flexible'' Palladium-PEPPSI Complexes in Air>, Quality Control of 112-63-0, the main research area is biphenyl preparation; chloride aryl boronic acid Suzuki Miyaura coupling palladium catalyst.

A series of Pd-PEPPSI complexes was designed and synthesized. The relationship between catalyst structure and properties was systematically investigated. It was revealed that “”bulky-yet-flexible”” C3 bearing acenaphthyl backbone was a highly efficient precatalyst and could be successfully employed in Suzuki-Miyaura reactions of (hetero)aryl chlorides ArCl (Ar = 4-CH3C6H4, pyridin-2-yl, thiophen-2-yl, etc.) with (hetero)arylboronic acids RB(OH)2 (R = C6H5, 2-OCH3C6H4, naphthalen-1-yl, etc.) at a low palladium loading in the presence of a weak inorganic base in air.

ChemCatChem published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bandyopadhyay, Sujoy; Ha, Su Ryong; Khan, M. Alam; Lee, Cheongbeom; Jeong, Hong In; Lokhandwala, Snehal; Tamboli, Mohaseen S.; Lee, Bo Ram; Boukhvalov, Danil W.; Choi, Hyosung published the artcile< Fabrication of conjugated porous polymer catalysts for oxygen reduction reactions: a bottom-up approach>, Category: esters-buliding-blocks, the main research area is porous polymer catalyst oxygen reduction reaction.

The present study demonstrates the fabrication of a conjugated porous polymer (CPP-P2) through a Pd-catalyzed Suzuki-Miyaura poly-condensation reaction. 13C cross-polarization solid-state NMR and Fourier transform IR (FTIR) spectroscopy were used to characterize CPP-P2. Pristine nitrogen-containing CPP was explored as a catalyst for the oxygen reduction reaction in 0.1 M KOH aqueous alk. media. In the case of CPP-P2, the polymer oxygen reduction reaction occurs via a four-electron transfer mechanism. An understanding of the oxygen reduction at the mol. level and the role of mol. packing in the three-dimensional structure was proposed based on d. functional theory (DFT) modeling.

Catalysts published new progress about Catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liang, Lu; Yan, Bin; Liu, Yueying; Jiang, Shiyao; He, Hua; Huang, Jingjing; Liu, Wenbin; Xie, Li published the artcile< Contributes to TMZ resistance, prognosis, and immune infiltration in GBM from a novel pyroptosis-associated risk signature>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is glioblastoma multiforme prognosis immune infiltration pyroptosis.

Pyroptosis is a form of programmed cell death, playing a significant role in cancer. Glioblastoma multiforme (GBM) is the most common malignant brain tumor. The poor prognosis in GBM due to temozolomide (TMZ) resistance has been widely discussed. Such being the case, the correlation between TMZ resistance and pyroptosis is seldom investigated. On this basis, this paper aims to explore the potential prognostic value of genes related to TMZ resistance and pyroptosis as well as their relationship to the immune microenvironment in GBM. A total of 103 patients from TCGA were assigned to a training cohort; 190 from CGGA were assigned to a validation cohort. The prognostic risk model reflecting pyroptosis and TMZ resistance was built from the training cohort using multivariate Cox regression and performed validation. RT-qPCR was used to examine the expression of 4 genes from the risk signature. FOXP3 was selected for overexpression and verified using the western blot. The TMZ IC50 of FOXP3-overexpressed cell lines was determined by CCK8. A four genes-based risk signature was established and validated, separating GBM patients into high- and low-risk groups. Compared with the low-risk group, the high-risk group presented worse clin. survival outcomes. Its differential expressed genes were enriched in immune-related pathways and closely related to the immune microenvironment. Moreover, RT-qPCR results suggested that FOXP3, IRF3, and CD274 were significantly upregulated in TMZ-resistant strains, while TP63 was downregulated. FOXP3-overexpressed GBM cell lines had higher TMZ IC50, implying an increased resistance of TMZ. A novel gene signature relevant to pyroptosis and TMZ resistance was constructed and could be used for the prognosis of GBM. The four genes from the risk model might play a potential role in antitumor immunity and serve as therapeutic targets for GBM.

Disease Markers published new progress about Adenosine A1 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Yang; Liu, Xun; Gao, Yahan; Tan, Rulan; Wu, Zhiyuan; Zhong, Qixin; Zeng, Feng published the artcile< Paeoniflorin Affects Hepatocellular Carcinoma Progression by Inhibiting Wnt/β-Catenin Pathway through Downregulation of 5-HT1D>, Category: esters-buliding-blocks, the main research area is hepatocellular carcinoma wnt beta catenin 5HT1D paeoniflorin; 5-HT1D; Hepatocellular carcinoma; Wnt/β-catenin pathway; migration; paeoniflorin; proliferation.

Background: Hepatocellular Carcinoma (HCC) is a primary liver cancer with high mortality. Paeoniflorin is a pinane monoterpene picroside with anti-tumor effect isolated from Chinese peony root and white peony root. Objective: The study was conducted to investigate the underlying mechanism of Paeoniflorin (PF) regulating Hepatocellular Carcinoma (HCC) progression via 5-hydroxytryptamine receptor 1D (5-HT1D). Methods: HepG2 and SMMC-7721 hepatoma cells were treated with different concentrations of PF (0, 5, 10, 20μM). Cell proliferation, apoptosis, migration, and invasion were examined by CCK-8 and colony formation assays, flow cytometry, wound healing assay, and transwell assay, resp. RTqPCR assay was used to detect the expression level of 5-HT1D, and Western blot assay was used to detect the expressions of 5-HT1D and Wnt/β-catenin pathway-related proteins. Results: With the increase in PF concentration, the mRNA levels of 5-HT1D in HepG2 and SMMC- 7721 hepatoma cells were decreased in a dose-dependent manner, and the proliferation, colony formation, migration and invasion ability of cells were gradually weakened, while the apoptosis rate was gradually increased. Overexpression of 5-HT1D significantly promoted the proliferation, colony formation, migration and invasion of HepG2 and SMMC-7721 cells, and increased the expression of Wnt/β-catenin pathway-related proteins, β -actenin, survivin, C-myc, and Cyclin D1. Furthermore, 5-HT1D overexpression could reverse the effect of PF on hepatoma cells and inhibit the expressions of Wnt/β-catenin pathway-related proteins. Conclusion: PF may inhibit the progression of HCC by blocking Wnt/β-catenin pathway expression through downregulating 5-HT1D.

Current Pharmaceutical Biotechnology published new progress about 5-HT1D receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lane, Rosemary; Cilibrasi, Chiara; Chen, Jianing; Shah, Kalpit; Messuti, Eleonora; Mazarakis, Nektarios K.; Stebbing, Justin; Critchley, Giles; Song, Erwei; Simon, Thomas; Giamas, Georgios published the artcile< PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling>, Category: esters-buliding-blocks, the main research area is PDGFR inhibitor cell differentiation DUSP1 p38MAPK signaling giloblastoma.

Glioblastoma (GBM) is the most common and fatal primary brain tumor in adults. Considering that resistance to current therapies leads to limited response in patients, new therapeutic options are urgently needed. In recent years, differentiation therapy has been proposed as an alternative for GBM treatment, with the aim of bringing cancer cells into a post-mitotic/differentiated state, ultimately limiting tumor growth. As an integral component of cancer development and regulation of differentiation processes, kinases are potential targets of differentiation therapies. The present study describes how the screening of a panel of kinase inhibitors (KIs) identified PDGF-Rα/β inhibitor CP-673451 as a potential differentiation agent in GBM. We show that targeting PDGF-Rα/β with CP-673451 in vitro triggers outgrowth of neurite-like processes in GBM cell lines and GBM stem cells (GSCs), suggesting differentiation into neural-like cells, while reducing proliferation and invasion in 3D hyaluronic acid hydrogels. In addition, we report that treatment with CP-673451 improves the anti-tumor effects of temozolomide in vivo using a s.c. xenograft mouse model. RNA sequencing and follow-up proteomic anal. revealed that upregulation of phosphatase DUSP1 and consecutive downregulation of phosphorylated-p38MAPK can underlie the pro-differentiation effect of CP-673451 on GBM cells. Overall, the present study identifies a potential novel therapeutic option that could benefit GBM patients in the future, through differentiation of residual GSCs post-surgery, with the aim to limit recurrence and improve quality of life.

Oncogene published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (ABCA1). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cordoba, Ruben; Plumet, Joaquin published the artcile< Pyridinium hydrobromide perbromide induces ipsobromodeformylation in o-hydroxy and o-methoxy substituted aromatic aldehydes>, Quality Control of 112-63-0, the main research area is aromatic aldehyde pyridinium hydrobromide perbromide ipsobromodeformylation; bromoarene preparation.

The reaction of o-hydroxy and o-methoxy substituted aromatic aldehydes with PHPB in pyridine gives aromatic bromination products including those arising from ipsobromodeformylation.

Tetrahedron Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tournaire, Guillaume; Loopmans, Shauni; Stegen, Steve; Rinaldi, Gianmarco; Eelen, Guy; Torrekens, Sophie; Moermans, Karen; Carmeliet, Peter; Ghesquiere, Bart; Thienpont, Bernard; Fendt, Sarah-Maria; van Gastel, Nick; Carmeliet, Geert published the artcile< Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle>, Application of C19H34O2, the main research area is Runx2 Tet1 self renewal skeletal progenitor proliferation mitochondrial respiration; CP: Metabolism; CP: Stem cell research; NAD regeneration; TCA rerouting; TET activity; cell-based regenerative medicine; electron transport chain; metabolic plasticity; proliferation; reverse succinate dehydrogenase; self-renewal; skeletal stem cells.

A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis. Accordingly, ETC inhibition decreases proliferation in cancer cells but does not seem to impair stem cell proliferation. However, it remains unclear how stem cells metabolically adapt. In this study, we show that pharmacol. inhibition of complex III of the ETC in skeletal stem and progenitor cells induces glycolysis side pathways and reroutes the tricarboxylic acid (TCA) cycle to regenerate NAD+ and preserve cell proliferation. These metabolic changes also culminate in increased succinate and 2-hydroxyglutarate levels that inhibit Ten-eleven translocation (TET) DNA demethylase activity, thereby preserving self-renewal and multilineage potential. Mechanistically, mitochondrial malate dehydrogenase and reverse succinate dehydrogenase activity proved to be essential for the metabolic rewiring in response to ETC inhibition. Together, these data show that the metabolic plasticity of skeletal stem and progenitor cells allows them to bypass ETC blockade and preserve their self-renewal.

Cell Reports published new progress about Adipogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics