Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Reference of 87-13-8.
Zhang, Bing;Dai, Xiwen;Bao, Ziyang;Mao, Qing;Duan, Yulin;Yang, Yuwei;Wang, Shaojie research published 《 Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives》, the research content is summarized as follows. A series of 2-[4-alkoxy-3-(1H-tetrazol-1-yl)phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives I (R =H, Me, Bn, etc.) with a tetrazole group targeting subpocket of the xanthine oxidase active site were designed, synthesized and they were further evaluated for their inhibitory potency against xanthine oxidase in vitro. All the tested compounds exhibited an apparent xanthine oxidase inhibitory potency, with IC50 values ranging from 0.0288μM to 0.629μM and the structure-activity relationship results revealed that the hydrophobic group at the 4′-position was indispensable for the inhibitory potency in vitro against xanthine oxidase. Compound I (R = 3-chlorobenzyl) emerged as the most potent xanthine oxidase inhibitor, with an IC50 value of 0.0288μM, which was comparable to febuxostat (IC50 = 0.0236μM) and a Lineweaver-Burk plot revealed of this compound acted as a mixed-type inhibitor for xanthine oxidase. Mol. modeling studies were performed to gain insights into the binding mode of this compound with xanthine oxidase which suggested that the tetrazole group of the Ph unit was accommodated in the subpocket, as expected. A potassium oxonate-induced hyperuricemia model in rats was chosen to further confirm the hypouricemic effect of the above compound and the result demonstrated that it could effectively reduce serum uric acid levels at an oral dose of 5 mg/kg, acute oral toxicity study in mice indicated that it was nontoxic and tolerated at a dose up to 2000 mg/kg.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Reference of 87-13-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics