Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Synthetic Route of 87-13-8.
Zambaldo, Claudio;Vinogradova, Ekaterina V.;Qi, Xiaotian;Iaconelli, Jonathan;Suciu, Radu M.;Koh, Minseob;Senkane, Kristine;Chadwick, Stormi R.;Sanchez, Brittany B.;Chen, Jason S.;Chatterjee, Arnab K.;Liu, Peng;Schultz, Peter G.;Cravatt, Benjamin F.;Bollong, Michael J. research published 《 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles》, the research content is summarized as follows. The emerging use of covalent ligands as chem. probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells, the KEAP1-NRF2 pathway, to discover cysteine-reactive electrophilic fragments from a reporter-based screen for NRF2 activation. This strategy identified a series of 2-sulfonylpyridines that selectively react with biol. thiols via nucleophilic aromatic substitution (SNAr). By tuning the electrophilicity and appended recognition elements, we demonstrate the potential of the 2-sulfonylpyridine reactive group with the discovery of a selective covalent modifier of adenosine deaminase (ADA). Targeting a cysteine distal to the active site, this mol. attenuates the enzymic activity of ADA and inhibits proliferation of lymphocytic cells. This study introduces a modular and tunable SNAr-based reactive group for targeting reactive cysteines in the human proteome and illustrates the pharmacol. utility of this electrophilic series.
Synthetic Route of 87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., 87-13-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics