Yu, Sul Hwa; Patra, Malay; Ferrari, Stefano; Ramirez Garcia, Paulina; Veldhuis, Nicholas A.; Kaminskas, Lisa M.; Graham, Bim; Quinn, John F.; Whittaker, Michael R.; Gasser, Gilles; Davis, Thomas P. published the artcile< Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles>, HPLC of Formula: 71195-85-2, the main research area is phototoxic organometallic rhenium complex star polymer drug delivery nanoparticle; human cervical cancer nanoparticle delivery.
We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(i) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N’-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(i) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations
Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Branched polymers, star-branched Role: SPN (Synthetic Preparation), PREP (Preparation). 71195-85-2 belongs to class esters-buliding-blocks, and the molecular formula is C9H3F5O2, HPLC of Formula: 71195-85-2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics