Glycerides are fatty acid esters of glycerol; they are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Related Products of 99769-19-4.
Yu, Lihong;Chen, Liandi;Luo, Guolin;Liu, Licai;Zhu, Wenqi;Yan, Pengke;Zhang, Peiquan;Zhang, Chao;Wu, Wenliao research published 《 Study on synthesis and biological evaluation of 3-aryl substituted xanthone derivatives as novel and potent tyrosinase inhibitors》, the research content is summarized as follows. A series of structure-based 3-aryl substituted xanthone derivatives I [R1 = H, COOH, OMe, OH, etc.; R2 = H, CHO, C(O)Me, OH, etc.; R3 = H, OMe, C(O)Me, COOH, etc.; R4 = H, OMe, OH] in which diverse functional groups were resp. attached on 3-aromatic ring moiety as new tyrosinase inhibitors was targeted. The results demonstrated that all obtained compounds had potent tyrosinase inhibitory activities with IC50 values at micromolar range. Especially, compound I (R1R2R4 = H, R3 = 4-OH) was found to be the most active tyrosinase inhibitor with the IC50 value of 11.3μ Especially, compound I (R1 = R2 = R4 = H, R3 = OH) (A) was found to be the most active tyrosinase inhibitor with the IC50 value of 11.3μM, uncovering that the introduction of the proper hydroxyl group in the 3-aromatic ring was beneficial for enhancing the inhibitory potency against tyrosinase. Moreover, the inhibition mechanism and inhibition kinetics studies revealed that compound A presented such inhibitory effect by acting as the reversible and competitive-uncompetitive mixed-II type inhibitor. Further mol. docking simulation showed that 3-aromatic ring of compound A was inserted into the narrow regions of binuclear copper-binding site at the bottom of the enzyme binding pocket, while the xanthone skeleton was positioned at the surface of tyrosinase. Taken together, these data suggested that such type of mols. might be utilized for the development of new and promising candidate for the treatment of depigmentation-related disorders.
99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Related Products of 99769-19-4
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