Xue, Dao-jin; Zhen, Zheng; Wang, Ke-xin; Zhao, Jia-lin; Gao, Yao; Chen, Yu-peng; Shen, You-bi; Peng, Zi-zhuang; Guan, Dao-gang; Huang, Tao published the artcile< Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage>, Category: esters-buliding-blocks, the main research area is sphingosine herbal medicine intracerebral hemorrhage; Chinese herbal medicine (CHM); Important gene network model; Integrated pharmacology; Intracerebral Hemorrhage (ICH); Mechanism.
Chinese herbal medicine (CHM) is characterized by “”multi- compounds, multi-targets and multi-pathway””, which has advanced benefits for preventing and treating complex diseases, but there still exists unsolved issues, mainly include unclear material basis and underlying mechanism of prescription. Integrated pharmacol. is a hot cross research area based on system biol., mathematics and poly-pharmacol. It can systematically and comprehensively investigate the therapeutic reaction of compounds or drugs on pathogenic genes network, and is especially suitable for the study of complex CHM systems. Intracerebral Hemorrhage (ICH) is one of the main causes of death among Chinese residents, which is characterized with high mortality and high disability rate. In recent years, the treatment of ICH by CHM has been deeply researched. Xue Fu Zhu Yu Decoction (XFZYD), one of the commonly used prescriptions in treating ICH at clinic level, has not been clear about its mechanism. Here, we established a strategy, which based on compounds-targets, pathogenetic genes, network anal. and node importance calculation Using this strategy, the core compounds group (CCG) of XFZYD was predicted and validated by in vitro experiments The mol. mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. The results show that the CCG with 43 compounds predicted by this model is highly consistent with the corresponding Compound-Target (C-T) network in terms of gene coverage, enriched pathway coverage and accumulated contribution of key nodes at 89.49%, 88.72% and 90.11%, resp., which confirmed the reliability and accuracy of the effective compound group optimization and mechanism speculation strategy proposed by us. Our strategy of optimizing the effective compound groups and inferring the mechanism provides a strategic reference for explaining the optimization and inferring the mol. mechanism of prescriptions in treating complex diseases of CHM.
BMC Complementary Medicine and Therapies published new progress about Algorithm, reliability. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.
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