Song, Ji-Xian; An, Ji-Ren; Chen, Qi; Yang, Xin-Yue; Jia, Cui-Ling; Xu, Shan; Zhao, Ya-shuo; Ji, En-Sheng published the artcile< Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice>, Formula: C15H22N2O2, the main research area is hepatic tissue ferroptosis iron; Liver; ferroptosis; high glucose; iron overload; liraglutide; oxidative stress.
Liver pathol. changes are as high as 21%-78% in diabetic patients, and treatment options are lacking. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor that is widely used in the clinic and is approved to treat obesity and diabetes. However, the specific protection mechanism needs to be clarified. In the present study, db/db mice were used to simulate Type 2 diabetes mellitus (T2DM), and they were i.p. injected daily with liraglutide (200μg/kg/d) for 5 wk. Hepatic function, pathol. changes, oxidative stress, iron levels, and ferroptosis were evaluated. First, liraglutide decreased serum AST and ALT levels, and suppressed liver fibrosis in db/db mice. Second, liraglutide inhibited the ROS production by upregulating SOD, GSH-PX, and GSH activity as well as by downregulating MDA, 4-HNE, and NOX4 expression in db/db mice. Furthermore, liraglutide attenuated iron deposition by decreasing TfR1 expression and increasing FPN1 expression. At the same time, liraglutide decreased ferroptosis by elevating the expression of SLC7A11 and the Nrf2/HO-1/GPX4 signaling pathway in the livers of db/db mice. In addition, liraglutide decreased the high level of labile iron pools (LIPs) and intracellular lipid ROS induced by high glucose in vitro. Therefore, we speculated that liraglutide played a crucial role in reducing iron accumulation, oxidative damage and ferroptosis in db/db mice.
Bioengineered published new progress about Adipocyte. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Formula: C15H22N2O2.
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